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CD33 anticorps (AA 15-237)

CD33 Reactivité: Humain FACS, WB, ELISA, IHC Hôte: Souris Monoclonal 2C6B7 unconjugated
N° du produit ABIN1724813
  • Antigène Voir toutes CD33 Anticorps
    CD33
    Épitope
    • 16
    • 16
    • 14
    • 13
    • 10
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-237
    Reactivité
    • 174
    • 35
    • 15
    • 13
    • 7
    • 6
    • 3
    • 1
    Humain
    Hôte
    • 100
    • 80
    Souris
    Clonalité
    • 95
    • 84
    • 1
    Monoclonal
    Conjugué
    • 60
    • 17
    • 14
    • 13
    • 11
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD33 est non-conjugé
    Application
    • 108
    • 107
    • 45
    • 35
    • 26
    • 26
    • 23
    • 22
    • 16
    • 13
    • 11
    • 9
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.
    Clone
    2C6B7
    Isotype
    IgG1
    Top Product
    Discover our top product CD33 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Deng, Liu, Wang, Tang, Ren, Xu, Ma, Wang, Zhuang, Wang, Chen: "The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease." dans: Human genetics, Vol. 131, Issue 7, pp. 1245-9, (2012) (PubMed).

    Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: "A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting." dans: mAbs, Vol. 3, Issue 1, pp. 21-30, (2011) (PubMed).

  • Antigène
    CD33
    Autre désignation
    CD33 (CD33 Produits)
    Synonymes
    anticorps SIGLEC-3, anticorps SIGLEC3, anticorps p67, anticorps Siglec-3, anticorps gp67, anticorps CD33 molecule, anticorps CD33 antigen, anticorps CD33, anticorps Cd33
    Sujet

    Description: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

    Aliases: p67, SIGLEC3, SIGLEC-3

    Poids moléculaire
    39.8 kDa
    ID gène
    945
    HGNC
    945
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