Botulinum Neurotoxin Type B (BoNT/B) anticorps

N° du produit ABIN179725

Détail du produit

Antigène: Botulinum Neurotoxin Type B (BoNT/B)

Reactivité: Clostridium botulinum

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Cell-ELISA (cELISA), Flow Cytometry (FACS)

Specificité: Anti-BoNT/B

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding BoNT/B

Clone: GR-3G7

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Concentration: 2 mg/mL

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détail du antigène

Antigène: Botulinum Neurotoxin Type B (BoNT/B)

Autre désignation: BoNT B, Lightchain (BoNT/B Produits)

Synonymes: anticorps botulinum neurotoxin type B, anticorps botulinum neurotoxin type B, BoNT/B, anticorps boNT/B, anticorps CLL_0038

Classe de substances: Bacteria

Sujet: Botulinum neurotoxin type B (BoNT/B) is produced by Clostridium botulinum, a genetically diverse class of anaerobic, spore-forming, gram-positive bacilli. Seven different botulinum toxin groups have been identified serologically and are called botulinum toxin type A,B,C,D,E,F, and G. BoNT/B is a two-chain polypeptide with a 100-kDa heavy chain, which is responsible for neurospecific binding joined by a disulphide bond to a 50-kDa light chain, a zinc-endopeptidase which blocks neurotransmitter release. BoNT/B is one of the most poisonous naturally occurring substances. It inhibits acetylcholine release from neuromuscular junctions while it is used as an important therapeutic mainstay in the treatment of spasticity disorders and as a cosmetic treatment.