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ApoE4 anticorps

Détails pour le produit réf. ABIN180022, Fournisseur: Connectez-vous pour afficher Nouveau
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Antigène
Reactivité
Humain
(12)
Hôte
Souris
(7), (5)
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
(1), (1), (1), (1), (1)
Application
Immunohistochimie (IHC), Transfer Western (WB)
(12), (6), (4), (1)
Pubmed 1 référence disponible
Fournisseur Connectez-vous pour afficher Nouveau
Numéro du produit fournisseur Connectez-vous pour afficher Nouveau
Quantité 200 μg
Destination France ( )
Disponibilité
Immunogène Synthetic peptide for a part of Human ApoE4
Clone 5B5
Isotype IgG1
Specificité Human ApoE4 specific, non-crossreactive with Human ApoE2 and ApoE3.
Purification Antigen peptide
Sujet Apolipoprotein-E (Apo-E) is a structural component of very low-density lipoprotein (VLDL) synthesized by the liver and intestinally synthesized chylomicrons. It is also a constituent of a subclass of high-density lipoproteins (HDLs) involved in cholesterol transport activity among cells. One of the most important roles of ApoE is to mediate high affinity binding of chylomicrons and VLDL particles that contain ApoE to the low-density lipoprotein (LDL) receptor. This allows for the specific uptake of these particles by the liver that is necessary for transport preventing the accumulation in plasma of cholesterol rich remnants. There are indications that ApoE is also involved in immune system regulation, nerve regeneration and muscle.
Indications d'application This antibody can be stained in formalin fixed paraffin embedded tissues after autoclave*1 (or microwave) treatment following formic acid treatment*2 by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1-020 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1-0 ug /ml. *1 1-10 for 1-0 minutes (10mM citric acid buffer pH6.0) *2 Rinsing by running water after formic acid treatment for 5 minutes following de-paraffin.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Supplier Images
Immunohistochimie (IHC) image for anti-ApoE4 anticorps (ABIN180022) Human Brain (Alzheimer Disease)
Transfer Western (WB) image for anti-ApoE4 anticorps (ABIN180022) anti-ApoE4 antibody (Image 2)
Produit citée dans: Kong, Bai, Sun et al.: "Expression of the Newly Identified Gene CAC1 in the Hippocampus of Alzheimer's Disease Patients." dans: Journal of molecular neuroscience : MN, 2012 (PubMed).

N° du produit ABIN180022

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