Souris anti-Humain IgA (Heavy Chain) Anticorps

Détails pour le produit réf. ABIN180873, Fournisseur: Connectez-vous pour afficher
Antigène
Épitope
Heavy Chain
200
162
131
49
39
19
16
16
16
6
6
3
3
3
2
2
2
1
1
1
1
Reactivité
Humain
767
194
122
76
48
48
38
36
36
34
27
23
14
13
7
5
4
3
3
3
2
1
1
1
Hôte
Souris
758
314
277
42
37
12
9
Clonalité (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Options
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Immunogène Reduced and alkylated Human IgA. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1myeloma cell line. Genename: IgA
Clone Mc24-2E11
Isotype IgG1
Purification Affinity Chromatography on Protein G.
Sujet Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.Synonyms: Human Immunoglobulin A
Poids moléculaire 160 kDa
Domaine de recherche Immunology, Secondary Antibodies
Indications d'application ELISA. Western Blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Agent conservateur Sodium azide
Précaution d'utilisation WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.
Background publications Creasey, Staalsoe, Raza, Arnot, Rowe: "Nonspecific immunoglobulin M binding and chondroitin sulfate A binding are linked phenotypes of Plasmodium falciparum isolates implicated in malaria during pregnancy." dans: Infection and immunity, Vol. 71, Issue 8, pp. 4767-71, 2003 (PubMed).