NFKB2 anticorps (C-Term)

N° du produit ABIN182483

Détail du produit anti-NFKB2 anticorps

Antigène: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Épitope: C-Term

Reactivité: Humain, Rat, Boeuf (Vache), Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: SDSDSDSEGP EKDTRSSFRG HTPLDLTCST LVKTLLLNAA QNTMEPPL

Homologie: Cow: 77%, Horse: 85%, Human: 100%, Pig: 77%, Rabbit: 92%, Rat: 77%

Attributs du produit: This is a rabbit polyclonal antibody against NFKB2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human NFKB2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 933 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NFKB2 (ABIN182483)

Wang, Yang, Li, Gong: "Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity." dans: Biochemical and biophysical research communications, Vol. 381, Issue 4, pp. 477-81, (2009) (PubMed).

Volger, Fledderus, Kisters, Fontijn, Moerland, Kuiper, van Berkel, Bijnens, Daemen, Pannekoek, Horrevoets: "Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis." dans: The American journal of pathology, Vol. 171, Issue 1, pp. 326-37, (2007) (PubMed).

Détails sur NFKB2

Antigène: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Autre désignation: NFKB2 (NFKB2 Produits)

Synonymes: anticorps NF-kappaB2, anticorps lyt, anticorps p49, anticorps p49/p100, anticorps p50B, anticorps p52, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100, anticorps Nfkb2

Sujet: NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
Alias Symbols: p52, H2TF1, LYT10, LYT-10
Protein Interaction Partner: FBXW11, UBC, RELB, RELA, REL, NFKB1, CHUK, BCL3, SUMO1, NEDD8, TNFAIP3, BIRC2, EPS8, VCP, UBD, BRRF1, COMMD1, COMMD2, MAP3K14, BTRC, NFKB2, FBXW7, TSG101, IKBKG, SUMO2, DPF2, PSMD11, NFKBIZ, TNIP2, HDAC5, NFKBIB, HDAC4, USP2, NFKBIE, RPL6, IKBKB, TSC22D3,
Protein Size: 900

Poids moléculaire: 97 kDa

ID gène: 4791

NCBI Accession: NM_002502, NP_002493

UniProt: Q00653

Pathways: Toll-Like Receptors Cascades