OTX2 anticorps (N-Term)

N° du produit ABIN182571

Détail du produit anti-OTX2 anticorps

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Poisson zèbre (Danio rerio), Chien, Mouton, Lapin, Cheval, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PESRVQVWFK NRRAKCRQQQ QQQQNGGQNK VRPAKKKTSP AREVSSESGT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against OTX2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human OTX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 297 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-OTX2 (ABIN182571)

Machali?ska, Kawa, Pius-Sadowska, Rogi?ska, K?os, Baumert, Wiszniewska, Machali?ski: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." dans: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).

Aluigi, Angelini, Corte, Falugi: "The sea urchin, Paracentrotus lividus, embryo as a "bioethical" model for neurodevelopmental toxicity testing: effects of diazinon on the intracellular distribution of OTX2-like proteins." dans: Cell biology and toxicology, Vol. 24, Issue 6, pp. 587-601, (2008) (PubMed).

Takeda, Yokoyama, Yasumoto, Saito, Udono, Takahashi, Shibahara: "OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium." dans: Biochemical and biophysical research communications, Vol. 300, Issue 4, pp. 908-14, (2003) (PubMed).

Détails sur OTX2

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Autre désignation: OTX2 (OTX2 Produits)

Synonymes: anticorps CPHD6, anticorps MCOPS5, anticorps E130306E05Rik, anticorps id:ibd2915, anticorps zOtx2, anticorps zgc:136535, anticorps zotx-2, anticorps Xotx-2, anticorps Xotx2, anticorps otx-2, anticorps otx2, anticorps orthodenticle homeobox 2, anticorps orthodenticle homeobox 2 S homeolog, anticorps orthodenticle homeobox 2 L homeolog, anticorps OTX2, anticorps Otx2, anticorps otx2, anticorps otx2.S, anticorps otx2.L

Sujet: Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. This protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Alias Symbols: MCOPS5, MGC45000, CPHD6
Protein Interaction Partner: ATXN1, CDK4, APP, DMBX1, TLE4, FOXA2, MITF, OTX2, LHX1,
Protein Size: 297

Poids moléculaire: 32 kDa

ID gène: 5015

NCBI Accession: NM_021728, NP_068374

Pathways: Dopaminergic Neurogenesis