ID4 anticorps (N-Term)

N° du produit ABIN183598

Détail du produit anti-ID4 anticorps

Antigène: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ID4 est non-conjugé

Application: Western Blotting (WB)

Séquence: MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC

Homologie: Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against ID4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ID4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 161 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ID4 (ABIN183598)

Melcher, Hartmann, Zopf, Herterich, Wilke, Müller, Rosler, Kudlich, Al-Taie, Rosenwald, Katzenberger, Scholtka, Seibold, Rogoll, Scheppach, Scheurlen, Lührs: "LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability." dans: Carcinogenesis, Vol. 32, Issue 4, pp. 636-42, (2011) (PubMed).

Détails sur ID4

Antigène: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Autre désignation: ID4 (ID4 Produits)

Synonymes: anticorps Idb4, anticorps bHLHb27, anticorps cb547, anticorps fb77d04, anticorps sb:cb547, anticorps wu:fb77d04, anticorps zgc:123214, anticorps bhlhb27, anticorps id4, anticorps id4a, anticorps idb4, anticorps IDB4, anticorps inhibitor of DNA binding 4, anticorps inhibitor of DNA binding 4, HLH protein, anticorps inhibitor of DNA binding 4, HLH protein S homeolog, anticorps Id4, anticorps id4, anticorps id4.S, anticorps ID4

Sujet: Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM].
Alias Symbols: IDB4, bHLHb27
Protein Interaction Partner: TCF3, TCF4, ID3, MYOD1, HES1,
Protein Size: 161

Poids moléculaire: 17 kDa

ID gène: 3400

NCBI Accession: NM_001546, NP_001537

UniProt: P47928