ZFP36 anticorps (N-Term)

N° du produit ABIN183636

Détail du produit anti-ZFP36 anticorps

Antigène: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFP36 est non-conjugé

Application: Western Blotting (WB)

Séquence: MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ZFP36. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ZFP36

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 326 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ZFP36

Antigène: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Autre désignation: ZFP36 (ZFP36 Produits)

Synonymes: anticorps G0S24, anticorps GOS24, anticorps NUP475, anticorps RNF162A, anticorps TIS11, anticorps TTP, anticorps zfp-36, anticorps c3h-1, anticorps g0s24, anticorps gos24, anticorps nup475, anticorps rnf162a, anticorps tis11, anticorps ttp, anticorps ZFP36, anticorps C3H-1, anticorps Gos24, anticorps Nup475, anticorps TIS11D, anticorps TISII, anticorps Tis11, anticorps Ttp, anticorps Zfp-36, anticorps ZFP36 ring finger protein, anticorps ZFP36 ring finger protein L homeolog, anticorps tristetraproline, anticorps Tristetraproline, anticorps similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth, anticorps zinc finger protein 36, anticorps ZFP36, anticorps zfp36.L, anticorps EDI_287240, anticorps Bm1_42085, anticorps LOAG_03119, anticorps zfp36, anticorps Zfp36

Sujet: ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Alias Symbols: TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A
Protein Interaction Partner: YWHAB, PPP2CA, DNAJB1, DCP1B, DHX36, PRR5L, XRN1, UBC, TRAF2, EXOSC6, UPF2, EXOSC8, YWHAQ, TNF, DCP2, EDC3, DCP1A, EDC4, CDK6, APP, LIN28A, SH3KBP1, PABPC1, NCL, MAP3K4, HSPA4, HDAC7, HDAC3, NFKB1, HOXC9, HDAC1, CCDC85B, MAPKAPK2, YWHAG, SFN, HMGB1, NUP21
Protein Size: 326

Poids moléculaire: 34 kDa

ID gène: 7538

NCBI Accession: NM_003407, NP_003398

UniProt: P26651