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Fibrillarin anticorps (N-Term)

FBL Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN183938
  • Antigène Voir toutes Fibrillarin (FBL) Anticorps
    Fibrillarin (FBL)
    Épitope
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 46
    • 23
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin
    Hôte
    • 39
    • 11
    • 1
    Lapin
    Clonalité
    • 38
    • 13
    Polyclonal
    Conjugué
    • 36
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Fibrillarin est non-conjugé
    Application
    • 49
    • 13
    • 11
    • 9
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    GGGFHSGGNR GRGRGGKRGN QSGKNVMVEP HRHEGVFICR GKEDALVTKN
    Homologie
    Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against FBL. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human FBL
    Top Product
    Discover our top product FBL Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 321 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ernoult-Lange, Wilczynska, Harper, Aigueperse, Dautry, Kress, Weil: "Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies." dans: Molecular biology of the cell, Vol. 20, Issue 1, pp. 176-87, (2009) (PubMed).

    Armistead, Khatkar, Meyer, Mark, Patel, Coghlan, Lamont, Liu, Wiechert, Cattini, Koetter, Wrogemann, Greenberg, Entian, Zelinski, Triggs-Raine: "Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome." dans: American journal of human genetics, Vol. 84, Issue 6, pp. 728-39, (2009) (PubMed).

  • Antigène
    Fibrillarin (FBL)
    Autre désignation
    FBL (FBL Produits)
    Synonymes
    anticorps FIB, anticorps FLRN, anticorps RNU3IP1, anticorps wu:fb37g12, anticorps zgc:56145, anticorps zgc:77130, anticorps FBL, anticorps AL022665, anticorps CG9888, anticorps Dmel\\CG9888, anticorps Fibri, anticorps GCR-6, anticorps GCR6, anticorps Pen59C5, anticorps fib, anticorps pen59C5, anticorps MGC76139, anticorps fbl, anticorps fibrillarin, anticorps Fibrillarin, anticorps putative fibrillarin, anticorps fibrillarin S homeolog, anticorps FBL, anticorps fbl, anticorps Fbl, anticorps Fib, anticorps fib1, anticorps LMJF_19_0100, anticorps fbl.S
    Sujet
    FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. FBL contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
    Alias Symbols: FIB, FLRN, RNU3IP1
    Protein Interaction Partner: UBC, CEP250, TP53, SUMO2, SUMO3, LIN28A, LIN28B, RPA3, RPA2, RPA1, ERG, RNF2, BMI1, SUZ12, EED, EZH2, TARDBP, UBD, NCL, ARFGEF1, PAN2, CBX8, ITGA4, FN1, VCAM1, MAGOH, EIF4A3, EEF1A1, DHX15, NSUN2, NOP58, MRTO4, GNL3, RSL1D1, SRRM2, BOP1, RRS1, EBNA1BP2, P
    Protein Size: 321
    Poids moléculaire
    35 kDa
    ID gène
    2091
    NCBI Accession
    NM_001436, NP_001427
    UniProt
    P22087
    Pathways
    Ribonucleoside Biosynthetic Process
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