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PCBP2 anticorps (Middle Region)

PCBP2 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN183983
  • Antigène Voir toutes PCBP2 Anticorps
    PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))
    Épitope
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 35
    • 20
    • 18
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval
    Hôte
    • 32
    • 4
    Lapin
    Clonalité
    • 30
    • 6
    Polyclonal
    Conjugué
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PCBP2 est non-conjugé
    Application
    • 24
    • 12
    • 12
    • 10
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ
    Homologie
    Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against PCBP2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human PCBP2
    Top Product
    Discover our top product PCBP2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 366 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lin, Yang, Liu, Tan, Wu, Hu, Jiang, Bao, Yuan, Qiang, Peng, Han: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." dans: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, (2016) (PubMed).

    Han, Xin, Zhao, Bao, Lin, Yin, Zhao, Yuan, Qiang, Peng: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." dans: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, (2013) (PubMed).

  • Antigène
    PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))
    Autre désignation
    PCBP2 (PCBP2 Produits)
    Synonymes
    anticorps HNRNPE2, anticorps HNRPE2, anticorps hnRNP-E2, anticorps AW412548, anticorps Hnrpx, anticorps alphaCP-2, anticorps PCBP3, anticorps fb36h02, anticorps wu:fb36h02, anticorps zgc:55964, anticorps PCBP2, anticorps poly(rC) binding protein 2, anticorps poly(rC) binding protein 2 L homeolog, anticorps PCBP2, anticorps Pcbp2, anticorps pcbp2, anticorps pcbp2.L
    Sujet
    PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.
    Alias Symbols: HNRPE2, hnRNP-E2
    Protein Interaction Partner: FUS, HUWE1, UBC, SNRPA, SUMO2, SUMO3, CEP250, MDM2, EED, TARDBP, ADRB2, IGSF8, HMGA1, CD81, HMGA2, WDR83, SLU7, CASK, UBL4A, VCAM1, PCBP2, NOS2, ITGA4, FN1, BRCA1, PRPF40A, SF3B2, NKAP, WDR77, PAXIP1, BARD1, PPIB, EEF1A1, FBXO6, UBD, PCBP1, QKI, CDK2, COP
    Protein Size: 366
    Poids moléculaire
    40 kDa
    ID gène
    5094
    NCBI Accession
    NM_005016, NP_005007
    UniProt
    Q6IPF4
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