CDK2 anticorps (AA 1-30)

N° du produit ABIN1881192

Détail du produit anti-CDK2 anticorps

Antigène: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Épitope: AA 1-30

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Ha, M, Rat, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human CDK2.

Clone: RB7918

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CDK2 (ABIN1881192)

Moshinsky, Bellamacina, Boisvert, Huang, Hui, Jancarik, Kim, Rice: "SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." dans: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 1026-31, (2003) (PubMed).

Chow, Siu, Ho, Ma, Ho, Poon: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." dans: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, (2003) (PubMed).

ONions, Allday: "Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2." dans: Oncogene, Vol. 22, Issue 46, pp. 7181-91, (2003) (PubMed).

Yun, Chae, Choi, Kim, Bang, Chung, Choi, Mantovani, Shin: "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway." dans: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36966-72, (2003) (PubMed).

Izumiya, Lin, Ellison, Levy, Mayeur, Izumiya, Kung: "Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest." dans: Journal of virology, Vol. 77, Issue 17, pp. 9652-61, (2003) (PubMed).

Détails sur CDK2

Antigène: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Autre désignation: CDK2 (CDK2 Produits)

Synonymes: anticorps p33(CDK2), anticorps A630093N05Rik, anticorps wu:fa10c02, anticorps zgc:56598, anticorps zgc:77684, anticorps eg1, anticorps CDKN2, anticorps cdk2L, anticorps cyclin dependent kinase 2, anticorps cyclin-dependent kinase 2, anticorps cyclin-dependent kinase 2 S homeolog, anticorps CDK2, anticorps Cdk2, anticorps cdk2, anticorps cdk2.S

Sujet: CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.

Poids moléculaire: 33930

NCBI Accession: NP_001789, NP_439892

UniProt: P24941

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA