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Estrogen Receptor alpha anticorps (C-Term)

ESR1 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal RB41149 unconjugated
N° du produit ABIN1881317
  • Antigène Voir toutes Estrogen Receptor alpha (ESR1) Anticorps
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Épitope
    • 32
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    • 26
    • 23
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    • 21
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    • 16
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 452-480, C-Term
    Reactivité
    • 481
    • 173
    • 167
    • 19
    • 18
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 392
    • 97
    • 2
    • 1
    Lapin
    Clonalité
    • 371
    • 123
    Polyclonal
    Conjugué
    • 223
    • 35
    • 24
    • 22
    • 19
    • 15
    • 15
    • 15
    • 15
    • 15
    • 15
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Estrogen Receptor alpha est non-conjugé
    Application
    • 377
    • 172
    • 142
    • 120
    • 96
    • 94
    • 80
    • 67
    • 40
    • 38
    • 24
    • 15
    • 10
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Homologie
    Hs, M, Pig, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This ESR1 isoform1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-480 amino acids from the C-terminal region of human ESR1 isoform1.
    Clone
    RB41149
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ESR1 Anticorps primaire
  • Indications d'application
    IF: 1:10~50. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." dans: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).

    Hayes, Skaar, Rae, Henry, Nguyen, Stearns, Li, Philips, Desta, Flockhart: "Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results." dans: Clinical pharmacology and therapeutics, Vol. 88, Issue 5, pp. 626-9, (2010) (PubMed).

    Lupien, Meyer, Bailey, Eeckhoute, Cook, Westerling, Zhang, Carroll, Rhodes, Liu, Brown: "Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance." dans: Genes & development, Vol. 24, Issue 19, pp. 2219-27, (2010) (PubMed).

  • Antigène
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Autre désignation
    ESR1 (ESR1 Produits)
    Synonymes
    anticorps LOC398734, anticorps AA420328, anticorps AU041214, anticorps ER-alpha, anticorps ER[a], anticorps ERa, anticorps ERalpha, anticorps ESR, anticorps Estr, anticorps Estra, anticorps Nr3a1, anticorps NR3A1, anticorps eralpha, anticorps zfER[a], anticorps ER, anticorps ESRA, anticorps ESTRR, anticorps Era, anticorps akap12, anticorps cb27, anticorps esr1, anticorps fb72g12, anticorps id:ibd1202, anticorps sb:cb27, anticorps si:ch73-192g21.1, anticorps wu:fb72g12, anticorps wu:fc21c03, anticorps Esr, anticorps RNESTROR, anticorps ERALPHA, anticorps er, anticorps esr, anticorps nr3a1, anticorps XER, anticorps era, anticorps esra, anticorps ERbeta, anticorps xesr-1, anticorps xlERalpha1, anticorps xlERalpha2, anticorps ESR1, anticorps estrogen receptor 1 L homeolog, anticorps estrogen receptor 1 (alpha), anticorps estrogen receptor 1, anticorps A kinase (PRKA) anchor protein 12b, anticorps esr1.L, anticorps Esr1, anticorps ESR1, anticorps esr1, anticorps akap12b
    Sujet
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    Poids moléculaire
    66216
    NCBI Accession
    NP_000116, NP_001116212, NP_001116213, NP_001116214
    UniProt
    P03372
    Pathways
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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