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PARP1 anticorps (pSer864)

PARP1 Reactivité: Humain DB Hôte: Lapin Polyclonal RB39168 unconjugated
N° du produit ABIN1881629
  • Antigène Voir toutes PARP1 Anticorps
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Épitope
    • 20
    • 18
    • 16
    • 15
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer864
    Reactivité
    • 239
    • 68
    • 51
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 220
    • 35
    • 1
    • 1
    Lapin
    Clonalité
    • 207
    • 50
    Polyclonal
    Conjugué
    • 150
    • 17
    • 16
    • 16
    • 15
    • 14
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PARP1 est non-conjugé
    Application
    • 167
    • 130
    • 68
    • 44
    • 34
    • 30
    • 28
    • 28
    • 24
    • 17
    • 16
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dot Blot (DB)
    Homologie
    B, Ha, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S864 of human PARP1.
    Clone
    RB39168
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PARP1 Anticorps primaire
  • Indications d'application
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Dong, Bey, Li, Kabbani, Yan, Xie, Hsieh, Gao, Boothman: "Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation." dans: Cancer research, Vol. 70, Issue 20, pp. 8088-96, (2010) (PubMed).

    Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." dans: Molecular cell, Vol. 39, Issue 5, pp. 736-49, (2010) (PubMed).

    Majewski, Thurston, Ramalingam, Kiela, Ghishan: "Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts." dans: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34828-38, (2010) (PubMed).

    Kim, Kang, Lee, Lee, Lee, Choi, Lee, Cho, Jin, Jheon, Son, Lee, Jung, Cha, Kim, Kang, Kam, Jung, Jheon, Park: "Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer." dans: Cancer science, Vol. 101, Issue 11, pp. 2436-42, (2010) (PubMed).

  • Antigène
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Autre désignation
    PARP1 (PARP1 Produits)
    Synonymes
    anticorps ADPRT, anticorps ADPRT 1, anticorps ADPRT1, anticorps ARTD1, anticorps PARP, anticorps PARP-1, anticorps PPOL, anticorps pADPRT-1, anticorps Adprt, anticorps Parp-1, anticorps 5830444G22Rik, anticorps AI893648, anticorps Adprp, anticorps Adprt1, anticorps C80510, anticorps parp-1, anticorps sPARP-1, anticorps BEST:LD21673, anticorps CG17685, anticorps CG17696, anticorps CG17718, anticorps CG40411, anticorps D.PARP, anticorps Dm.pARTa, anticorps Dmel\\CG40411, anticorps LD21673.3prime, anticorps PARP1, anticorps dPARP, anticorps parp, anticorps adprt1, anticorps padprt-1, anticorps ppol, anticorps si:dkey-206f10.3, anticorps wu:fc60f12, anticorps zgc:110092, anticorps poly(ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase family, member 1, anticorps Poly-(ADP-ribose) polymerase, anticorps poly(ADP-ribose) polymerase 1 L homeolog, anticorps PARP1, anticorps Parp1, anticorps Parp, anticorps parp1.L, anticorps parp1
    Sujet
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
    Poids moléculaire
    113084
    NCBI Accession
    NP_001609
    UniProt
    P09874
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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