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p107 anticorps (C-Term)

RBL1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB40387 unconjugated
N° du produit ABIN1881732
  • Antigène Voir toutes p107 (RBL1) Anticorps
    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
    Épitope
    • 19
    • 15
    • 8
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1007-1035, C-Term
    Reactivité
    • 81
    • 20
    • 10
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 76
    • 5
    Lapin
    Clonalité
    • 77
    • 4
    Polyclonal
    Conjugué
    • 34
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp p107 est non-conjugé
    Application
    • 66
    • 40
    • 27
    • 27
    • 11
    • 10
    • 7
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This RBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1007-1035 amino acids from the C-terminal region of human RBL1.
    Clone
    RB40387
    Isotype
    Ig Fraction
    Top Product
    Discover our top product RBL1 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Jayadeva, Kurimchak, Garriga, Sotillo, Davis, Haines, Mumby, Graña: "B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation." dans: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29863-73, (2010) (PubMed).

    Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." dans: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

    Cunningham, Vierkant, Sellers, Phelan, Rider, Liebow, Schildkraut, Berchuck, Couch, Wang, Fridley, Gentry-Maharaj, Menon, Hogdall, Kjaer, Whittemore, DiCioccio, Song, Gayther, Ramus, Pharaoh, Goode: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." dans: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, (2009) (PubMed).

  • Antigène
    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
    Autre désignation
    RBL1 (RBL1 Produits)
    Synonymes
    anticorps p107, anticorps prb1, anticorps fj58e06, anticorps wu:fj58e06, anticorps CP107, anticorps PRB1, anticorps AW547426, anticorps retinoblastoma-like 1 L homeolog, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma-like 1 (p107), anticorps retinoblastoma-like 1, anticorps rbl1.L, anticorps RBL1, anticorps rbl1, anticorps Rbl1
    Sujet
    The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
    Poids moléculaire
    120847
    NCBI Accession
    NP_002886, NP_899662
    UniProt
    P28749
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases
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