Src anticorps (N-Term)

N° du produit ABIN1881833

Détail du produit anti-Src anticorps

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Épitope: AA 24-52, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Src est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human SRC.

Clone: RB41141

Isotype: IgG

Information d'application

Indications d'application: IF: 1:50. IF: 1:50. WB: 1:2000. IHC-P: 1:50. IHC-P: 1:50. FC: 1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Src (ABIN1881833)

Kieslinger, Hiechinger, Dobreva, Consalez, Grosschedl: "Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner." dans: Cell stem cell, Vol. 7, Issue 4, pp. 496-507, (2010) (PubMed).

Pradhan, Alrehani, Patel, Khatlani, Vijayan: "Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen." dans: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29059-68, (2010) (PubMed).

Dergai, Tsyba, Dergai, Zlatskii, Skrypkina, Kovalenko, Rynditch: "Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface." dans: Biochemical and biophysical research communications, Vol. 399, Issue 2, pp. 307-12, (2010) (PubMed).

Liu, Qiu, Li, Chen, Cao et al.: "Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via ..." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 21934-42, (2010) (PubMed).

Pene-Dumitrescu, Smithgall: "Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner." dans: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21446-57, (2010) (PubMed).

Détails sur Src

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Autre désignation: SRC (Src Produits)

Synonymes: anticorps AW259666, anticorps pp60c-src, anticorps C-src1, anticorps CG7524, anticorps D-Src64B, anticorps D-src, anticorps DSRC64, anticorps DSrc, anticorps DSrc64, anticorps DSrc64B, anticorps Dm SRC1, anticorps DmHD-358, anticorps Dmel\CG7524, anticorps Dsrc, anticorps Dsrc64, anticorps Dsrc64B, anticorps HD-358, anticorps MRE5, anticorps SRC 64B, anticorps Src, anticorps Src1, anticorps Src64, anticorps c-src, anticorps dSrc, anticorps dsrc, anticorps src, anticorps src1, anticorps src64, anticorps src64B, anticorps src64b, anticorps ASV, anticorps SRC1, anticorps c-SRC, anticorps p60-Src, anticorps c-Src, anticorps PP60C-SCR, anticorps SDR, anticorps SRC proto-oncogene, non-receptor tyrosine kinase, anticorps uncharacterized LOC5574802, anticorps proto-oncogene tyrosine-protein kinase src, anticorps Rous sarcoma oncogene, anticorps Src oncogene at 64B, anticorps SRC, anticorps LOC5574802, anticorps CpipJ_CPIJ010659, anticorps Src, anticorps Src64B

Classe de substances: Viral Protein

Sujet: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Poids moléculaire: 59835

NCBI Accession: NP_005408, NP_938033

UniProt: P12931

Pathways: Signalistation JAK/STAT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling