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GRK4 anticorps (C-Term)

GRK4 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB0901 unconjugated
N° du produit ABIN1882085
  • Antigène Voir toutes GRK4 Anticorps
    GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))
    Épitope
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 549-577, C-Term
    Reactivité
    • 27
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 21
    • 7
    Lapin
    Clonalité
    • 22
    • 6
    Polyclonal
    Conjugué
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRK4 est non-conjugé
    Application
    • 17
    • 12
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This GRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-577 amino acids from the C-terminal region of human GRK4.
    Clone
    RB0901
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GRK4 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Villar, Jones, Armando, Palmes-Saloma, Yu, Pascua, Keever, Arnaldo, Wang, Luo, Felder, Jose: "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." dans: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21425-34, (2009) (PubMed).

    Perroy, Adam, Qanbar, Chénier, Bouvier: "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4." dans: The EMBO journal, Vol. 22, Issue 15, pp. 3816-24, (2003) (PubMed).

    Watanabe, Xu, Bengra, Jose, Felder: "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4." dans: Kidney international, Vol. 62, Issue 3, pp. 790-8, (2002) (PubMed).

    Sallese, Mariggiò, Collodel, Moretti, Piomboni, Baccetti, De Blasi: "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." dans: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10188-95, (1997) (PubMed).

    Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." dans: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6403-10, (1996) (PubMed).

    Sallese, Lombardi, De Blasi: "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." dans: Biochemical and biophysical research communications, Vol. 199, Issue 2, pp. 848-54, (1994) (PubMed).

  • Antigène
    GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))
    Autre désignation
    GRK4 (GRK4 Produits)
    Synonymes
    anticorps GPRK2L, anticorps GPRK4, anticorps GRK4a, anticorps IT11, anticorps A830025H08Rik, anticorps GRK, anticorps Gprk2l, anticorps Gprk4, anticorps AMPK, anticorps AMPKalpha, anticorps CG3051, anticorps DmAMPK alpha, anticorps Dmel\\CG3051, anticorps EG:132E8.2, anticorps FBgn0023169, anticorps Gprk-4, anticorps ampk, anticorps ampkalpha, anticorps dAMPKa, anticorps dAMPKalpha, anticorps snf1a, anticorps gprk4, anticorps gprk4-a, anticorps grk4, anticorps GRK4, anticorps gprk4-b, anticorps zgc:153020, anticorps gprk2l, anticorps grk4a, anticorps it11, anticorps G protein-coupled receptor kinase 4, anticorps AMP-activated protein kinase alpha subunit, anticorps G protein-coupled receptor kinase 4 L homeolog, anticorps G protein-coupled receptor kinase 4 S homeolog, anticorps GRK4, anticorps Grk4, anticorps AMPKalpha, anticorps grk4.L, anticorps grk4.S, anticorps grk4, anticorps LOC100540688
    Sujet
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
    Poids moléculaire
    66583
    NCBI Accession
    NP_001004056, NP_001004057, NP_892027
    UniProt
    P32298
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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