Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

MEK1 anticorps (N-Term)

MAP2K1 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB3593 unconjugated
N° du produit ABIN1882101
  • Antigène Voir toutes MEK1 (MAP2K1) Anticorps
    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
    Épitope
    • 46
    • 28
    • 28
    • 23
    • 22
    • 22
    • 20
    • 19
    • 18
    • 16
    • 15
    • 14
    • 11
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivité
    • 375
    • 205
    • 200
    • 37
    • 30
    • 18
    • 16
    • 12
    • 12
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 339
    • 33
    • 3
    • 2
    • 2
    Lapin
    Clonalité
    • 292
    • 87
    Polyclonal
    Conjugué
    • 180
    • 25
    • 22
    • 17
    • 15
    • 14
    • 14
    • 12
    • 12
    • 12
    • 12
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MEK1 est non-conjugé
    Application
    • 246
    • 124
    • 103
    • 68
    • 66
    • 46
    • 33
    • 32
    • 25
    • 15
    • 11
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Rb, Rat
    Purification
    This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogène
    This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).
    Clone
    RB3593
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP2K1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." dans: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).

    Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." dans: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

    Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." dans: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, (2003) (PubMed).

    Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." dans: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, (2003) (PubMed).

    Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." dans: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, (2003) (PubMed).

  • Antigène
    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
    Autre désignation
    MEK1 (MAP2K1) (MAP2K1 Produits)
    Synonymes
    anticorps Mek1, anticorps CFC3, anticorps MAPKK1, anticorps MEK1, anticorps MKK1, anticorps PRKMK1, anticorps MEKK1, anticorps Prkmk1, anticorps mek-2, anticorps si:ch211-242m18.2, anticorps wu:fj56a12, anticorps wu:fj61b01, anticorps zgc:56557, anticorps ATMEK1, anticorps F20B18.180, anticorps F20B18_180, anticorps MAP kinase/ ERK kinase 1, anticorps MITOGEN ACTIVATED PROTEIN KINASE KINASE, anticorps MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, anticorps NMAPKK, anticorps MEK, anticorps mitogen activated protein kinase kinase 1, anticorps mitogen-activated protein kinase kinase 1, anticorps mitogen-activated protein kinase kinase 1 L homeolog, anticorps MAP kinase/ ERK kinase 1, anticorps Map2k1, anticorps MAP2K1, anticorps map2k1.L, anticorps map2k1, anticorps MEK1
    Sujet
    MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
    Poids moléculaire
    43439
    NCBI Accession
    NP_002746
    UniProt
    Q02750
    Pathways
    Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
Vous êtes ici:
Support technique