This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogène
This CYP1A1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 377-405 amino acids from the C-terminal region of human CYP1A1.
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Licznerska, Szaefer, Wierzchowski, Sobierajska, Baer-Dubowska: "Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation." dans: Molecular and cellular biochemistry, Vol. 425, Issue 1-2, pp. 169-179, (2017) (PubMed).
Pande, Amos, Eng, Frazier: "Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis." dans: Molecular carcinogenesis, Vol. 49, Issue 11, pp. 974-80, (2010) (PubMed).
Sabitha, Reddy, Jamil: "Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer." dans: Cancer epidemiology, Vol. 34, Issue 5, pp. 587-92, (2010) (PubMed).
Kumar, Yadav, Singh, Goel, Ahmed, Gupta, Grover, Banerjee: "CYP 1A1 polymorphism and organochlorine pesticides levels in the etiology of prostate cancer." dans: Chemosphere, Vol. 81, Issue 4, pp. 464-8, (2010) (PubMed).
Yamaguti, Lourenço, Silveira, Tone, Lopes, Lima: "Increased risk for acute lymphoblastic leukemia in children with cytochrome P450A1 (CYP1A1)- and NAD(P)H:quinone oxidoreductase 1 (NQO1)-inherited gene variants." dans: Acta haematologica, Vol. 124, Issue 3, pp. 182-4, (2010) (PubMed).
Antigène
CYP1A1
(Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))
anticorps AHH, anticorps AHRR, anticorps CP11, anticorps CYP1, anticorps P1-450, anticorps P450-C, anticorps P450DX, anticorps Cyp1a2, anticorps P450-1, anticorps cyp1a1, anticorps CYP1A1, anticorps CYPIA1, anticorps Cyp45c, anticorps Cypc45c, anticorps P-450MC, anticorps wu:fb63b04, anticorps zfCYP1A, anticorps zgc:109747, anticorps ahh, anticorps ahrr, anticorps cp11, anticorps cyp1, anticorps cyp1a, anticorps p1-450, anticorps p450-c, anticorps p450dx, anticorps cytochrome P450 family 1 subfamily A member 1, anticorps cytochrome P450 1A1, anticorps cytochrome P450, family 1, subfamily a, polypeptide 1, anticorps cytochrome P450, family 1, subfamily A, polypeptide 1, anticorps cytochrome P450 family 1 subfamily D polypeptide 1, anticorps cytochrome P4501A1, anticorps polycyclic hydrocarbon-inducible cytochrome P450c, anticorps cytochrome P450, family 1, subfamily A, anticorps cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, anticorps cytochrome P450 family 1 subfamily A member 1 L homeolog, anticorps CYP1A1, anticorps CpipJ_CPIJ010542, anticorps Cyp1a1, anticorps cyp1d1, anticorps LOC100328613, anticorps cyp1a, anticorps LOC102129994, anticorps cyp1a1.L
Sujet
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown, however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.