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STAT5A anticorps (pTyr694)

STAT5A Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN196696
  • Antigène Voir toutes STAT5A Anticorps
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Épitope
    • 56
    • 24
    • 17
    • 15
    • 15
    • 14
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
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    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
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    • 1
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    • 1
    • 1
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    • 1
    • 1
    • 1
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    pTyr694
    Reactivité
    • 205
    • 110
    • 83
    • 25
    • 14
    • 9
    • 9
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 178
    • 30
    • 2
    Lapin
    Clonalité
    • 158
    • 52
    Polyclonal
    Conjugué
    • 119
    • 10
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp STAT5A est non-conjugé
    Application
    • 163
    • 69
    • 59
    • 40
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    • 30
    • 24
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    • 2
    • 2
    • 1
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    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of STAT5A only when phosphorylated at Tyrosine 694.
    Purification
    Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    Synthesized phosphopeptide derived from Human STAT5A around the phosphorylation site of Tyrosine 694 (D-G-Yp-V-K).
    Top Product
    Discover our top product STAT5A Anticorps primaire
  • Indications d'application
    Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 M NaCl, 0.02 % Sodium Azide, 50 % Glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C.
  • Antigène
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Autre désignation
    STAT5 / STAT5A (STAT5A Produits)
    Synonymes
    anticorps MGF, anticorps STAT5, anticorps AA959963, anticorps Stat5, anticorps STAT5A/MGF, anticorps STATA5, anticorps STAT5A, anticorps stat5, anticorps stat5b, anticorps signal transducer and activator of transcription 5A, anticorps signal transducer and activator of transcription 5a, anticorps STAT5A, anticorps Stat5a, anticorps stat5a, anticorps LOC100348518, anticorps LOC100716811
    Sujet
    The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT5 is activated in response to prolactine, growth hormone, GM-CSF, and IL-2.Synonyms: MGF, Mammary gland factor, STAT-5, STAT-5A, Signal transducer and activator of transcription 5A
    Poids moléculaire
    90 kDa
    ID gène
    6776
    NCBI Accession
    NP_003143
    UniProt
    P42229
    Pathways
    Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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