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MAP2K3 anticorps (Ser189)

MAP2K3 Reactivité: Humain, Rat WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN197297
  • Antigène Voir toutes MAP2K3 Anticorps
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    Épitope
    • 25
    • 19
    • 15
    • 15
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser189
    Reactivité
    • 141
    • 101
    • 81
    • 11
    • 10
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 144
    • 12
    Lapin
    Clonalité
    • 130
    • 26
    Polyclonal
    Conjugué
    • 72
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Cet anticorp MAP2K3 est non-conjugé
    Application
    • 122
    • 49
    • 40
    • 39
    • 33
    • 28
    • 22
    • 9
    • 9
    • 8
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    MKK3 antibody AP02647PU detects endogenous levels of total MKK3 protein.
    Purification
    Affinity chromatography
    Immunogène
    Synthetic non-phosphopeptide derived from human MKK3 around the phosphorylation site of serine189 (V-D-Sp-V-A).
    Top Product
    Discover our top product MAP2K3 Anticorps primaire
  • Indications d'application
    Suitable for use in Western blot (1: 500-1: 1000) and Immunohistochemistry (1: 50-1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C.
  • Antigène
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    Autre désignation
    MAP2K3 (MAP2K3 Produits)
    Synonymes
    anticorps MAPKK3, anticorps MEK3, anticorps MKK3, anticorps PRKMK3, anticorps SAPKK-2, anticorps SAPKK2, anticorps AW212142, anticorps Prkmk3, anticorps mMKK3b, anticorps Mkk3, anticorps mitogen-activated protein kinase kinase 3, anticorps mitogen activated protein kinase kinase 3, anticorps MAP kinase activator XMEK3, anticorps MAP2K3, anticorps Map2k3, anticorps map2k3
    Sujet
    MEK3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Synonyms: Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MEK3, MKK3
    ID gène
    5606
    NCBI Accession
    NP_002747
    UniProt
    P46734
    Pathways
    Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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