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IRS1 anticorps (Ser636)

IRS1 Reactivité: Humain, Souris, Rat WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN197466
  • Antigène Voir toutes IRS1 Anticorps
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Épitope
    • 31
    • 28
    • 23
    • 21
    • 21
    • 21
    • 19
    • 17
    • 16
    • 16
    • 16
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser636
    Reactivité
    • 294
    • 236
    • 212
    • 23
    • 19
    • 18
    • 17
    • 16
    • 16
    • 15
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 291
    • 17
    Lapin
    Clonalité
    • 284
    • 24
    Polyclonal
    Conjugué
    • 140
    • 14
    • 13
    • 12
    • 12
    • 12
    • 12
    • 12
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    Cet anticorp IRS1 est non-conjugé
    Application
    • 174
    • 126
    • 104
    • 93
    • 92
    • 67
    • 57
    • 52
    • 24
    • 20
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody AP02732PU detects endogenous levels of total IRS-1 protein.
    Purification
    Immunoaffinity Chromatography using epitope-specific immunogen.
    Immunogène
    The antiserum was produced against synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
    Top Product
    Discover our top product IRS1 Anticorps primaire
  • Indications d'application
    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C.
  • Antigène
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Autre désignation
    IRS1 (IRS1 Produits)
    Synonymes
    anticorps HIRS-1, anticorps G972R, anticorps IRS-1, anticorps IRS1IRM, anticorps irs1, anticorps irsu, anticorps IRS1, anticorps irs-1, anticorps irs1-a, anticorps insulin receptor substrate 1, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 1 S homeolog, anticorps IRS1, anticorps Irs1, anticorps irs2, anticorps irs1.S
    Sujet
    Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.Synonyms: IRS-1, Insulin receptor substrate 1
    ID gène
    3667
    NCBI Accession
    NP_005535
    UniProt
    P35568
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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