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Desmoglein 2 anticorps

DSG2 Reactivité: Humain WB, IHC (fro) Hôte: Souris Monoclonal 6D8 unconjugated
N° du produit ABIN2191994
  • Antigène Voir toutes Desmoglein 2 (DSG2) Anticorps
    Desmoglein 2 (DSG2)
    Reactivité
    • 89
    • 37
    • 34
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 72
    • 17
    Souris
    Clonalité
    • 63
    • 26
    Monoclonal
    Conjugué
    • 42
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Desmoglein 2 est non-conjugé
    Application
    • 76
    • 26
    • 22
    • 18
    • 16
    • 13
    • 13
    • 13
    • 10
    • 6
    • 5
    • 2
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Réactivité croisée (Details)
    Cross reactivity: Human desmoglein-1 : No, Human desmoglein-3 : No
    Stérilité
    0.2 μm filtered
    Clone
    6D8
    Isotype
    IgG1
    Top Product
    Discover our top product DSG2 Anticorps primaire
  • Indications d'application
    For immune fluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Positive A431 Cells control
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Ota, Amagai, Watanabe, Nishikawa: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases." dans: Journal of dermatological science, Vol. 32, Issue 2, pp. 137-41, (2003) (PubMed).

    Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: "Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains." dans: Journal of cell science, Vol. 109 ( Pt 5), pp. 1143-54, (1996) (PubMed).

  • Antigène
    Desmoglein 2 (DSG2)
    Autre désignation
    Desmoglein-2 (DSG2 Produits)
    Synonymes
    anticorps DSG2, anticorps dsc, anticorps dsga, anticorps si:dkeyp-51f12.6, anticorps wu:fj23f02, anticorps ARVC10, anticorps ARVD10, anticorps CDHF5, anticorps CMD1BB, anticorps HDGC, anticorps AA408168, anticorps D18Ertd293e, anticorps desmoglein 2, anticorps desmoglein 2, tandem duplicate 1, anticorps DSG2, anticorps dsg2.1, anticorps dsg2, anticorps Dsg2
    Sujet
    The monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts. In human, four desmogleins have been identified (Dsg1-4). Desmogleins are synthesized with a signal peptide that directs them to the endoplasmic reticulum and a proregion that is removed during protein processing. The mature protein includes four highly conserved extracellular domains (EC 1-4) and a fifth membrane proximal, more variable EC domain that is referred to as the "extracellular anchor domain. Desmoglein-2 is expressed on various cells including simple epithelia and myocardium, tumors and and many cell cultures. Desmogleins play critical roles in cell adhesion and skin blistering diseases, as they are the target antigens of autoimmune antibodies and bacterial toxins. Desmosomal dysfunction has been implicated in a number of diseases, including striate palmoplantar keratoderma, skin fragility, and ectodermal dysplasia, and most recently arrhythmic right ventricular cardiomyopathy (ARVC). Aliases Dsg2, Cadherin family member 5, HDGC Immunogen Extracellular EC4 domain
    Pathways
    Cell-Cell Junction Organization
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