Lactoferrin anticorps

N° du produit ABIN2192193

Détail du produit anti-Lactoferrin anticorps

Antigène: Lactoferrin (LTF) (Lactotransferrin (LTF))

Reactivité: Humain

Hôte: Cow

Clonalité: Polyclonal

Conjugué: Cet anticorp Lactoferrin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-Lactoferrin (ABIN2192193)

van Veen, Geerts, van Berkel, Nuijens: "Analytical cation-exchange chromatography to assess the identity, purity, and N-terminal integrity of human lactoferrin." dans: Analytical biochemistry, Vol. 309, Issue 1, pp. 60-6, (2002) (PubMed).

Nibbering, Ravensbergen, Welling, van Berkel, van Berkel, Pauwels, Nuijens: "Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria." dans: Infection and immunity, Vol. 69, Issue 3, pp. 1469-76, (2001) (PubMed).

Nuijens, van Berkel, Geerts, Hartevelt, de Boer, van Veen, Pieper: "Characterization of recombinant human lactoferrin secreted in milk of transgenic mice." dans: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8802-7, (1997) (PubMed).

Détails sur Lactoferrin

Antigène: Lactoferrin (LTF) (Lactotransferrin (LTF))

Autre désignation: Lactoferrin (LTF Produits)

Synonymes: anticorps LTF, anticorps GIG12, anticorps HLF2, anticorps LF, anticorps Lf, anticorps Csp82, anticorps MMS10R, anticorps Ms10r, anticorps PLF, anticorps TFEW, anticorps conalbumin, anticorps lactotransferrin, anticorps transferrin, anticorps transferrin (ovotransferrin), anticorps LTF, anticorps CpipJ_CPIJ000114, anticorps TF, anticorps Ltf

Sujet: Human lactoferrin (LF) is an 80 kDa glycoprotein which was first isolated from human milk. It plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N- terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway. Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.

Pathways: Transition Metal Ion Homeostasis