Endoglin anticorps

N° du produit ABIN238459

Détail du produit anti-Endoglin anticorps

Antigène: Endoglin (ENG)

Reactivité: Humain, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Endoglin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Réactivité croisée (Details): Species reactivity (tested):Human, Porcine.

Attributs du produit: Synonyms: ENG, END, HHT1, ORW, ORW1

Purification: Protein-A Affinity Chromatography

Immunogène: Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.

Clone: MEM-229

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry: 10 μg/mLPositive Control: Kg1 Human acute myelogenous leukemia cell lineWestern Blotting (Non-Reducing Conditions).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-Endoglin (ABIN238459)

Koch, Staffler, Hüttinger, Hilgert, Prager, Cerný, Steinlein, Majdic, Horejsí, Stockinger: "T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density." dans: International immunology, Vol. 11, Issue 5, pp. 777-86, (1999) (PubMed).

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: CD105 / Endoglin (ENG Produits)

Synonymes: anticorps ENG, anticorps MGC137842, anticorps DKFZp469D0419, anticorps END, anticorps HHT1, anticorps ORW1, anticorps AI528660, anticorps AI662476, anticorps CD105, anticorps S-endoglin, anticorps endoglin, anticorps ENG, anticorps Eng

Sujet: CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1

UniProt: P17813