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UPF3B anticorps

UPF3B Reactivité: Humain, Chien WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2462297
  • Antigène Voir toutes UPF3B Anticorps
    UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
    Reactivité
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Chien
    Hôte
    • 13
    Lapin
    Clonalité
    • 13
    Polyclonal
    Conjugué
    • 10
    • 1
    • 1
    • 1
    Cet anticorp UPF3B est non-conjugé
    Application
    • 8
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Antibody is purified by protein A chromatography method.
    Immunogène
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UPF3B.
    Top Product
    Discover our top product UPF3B Anticorps primaire
  • Indications d'application
    UPF3B antibody can be used for detection of UPF3B by ELISA at 1:312500. UPF3B antibody can be used for detection of UPF3B by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    Concentration
    1 mg/mL
    Buffer
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    Conseil sur la manipulation
    As with any antibody avoid repeat freeze-thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store UPF3B antibody at -20 °C.
  • Antigène
    UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
    Autre désignation
    UPF3B (UPF3B Produits)
    Synonymes
    anticorps HUPF3B, anticorps MRXS14, anticorps RENT3B, anticorps UPF3X, anticorps 5730594O13Rik, anticorps AI317193, anticorps AW541158, anticorps RGD1560264, anticorps UPF3B, regulator of nonsense mediated mRNA decay, anticorps UPF3 regulator of nonsense transcripts homolog B (yeast), anticorps UPF3B, anticorps Upf3b
    Sujet
    UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
    Poids moléculaire
    52 kDa, 58 kDa
    ID gène
    65109
    NCBI Accession
    NP_075386
    UniProt
    Q9BZI7
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