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HSPD1 anticorps

HSPD1 Reactivité: Humain, Souris, Rat, Poulet, Singe, Chien, Hamster, Boeuf (Vache), Lapin, Porc, Cobaye, Bactéries, Saccharomyces cerevisiae, Plantes, Mouche blanche WB, FACS, IHC (fro) Hôte: Souris Monoclonal LK2 unconjugated
N° du produit ABIN263948
  • Antigène Voir toutes HSPD1 Anticorps
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    Reactivité
    • 214
    • 126
    • 122
    • 74
    • 71
    • 69
    • 64
    • 62
    • 61
    • 60
    • 46
    • 41
    • 36
    • 26
    • 25
    • 21
    • 17
    • 17
    • 14
    • 14
    • 13
    • 11
    • 10
    • 10
    • 10
    • 10
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Poulet, Singe, Chien, Hamster, Boeuf (Vache), Lapin, Porc, Cobaye, Bactéries, Saccharomyces cerevisiae, Plantes, Mouche blanche
    Hôte
    • 125
    • 117
    • 3
    Souris
    Clonalité
    • 128
    • 115
    Monoclonal
    Conjugué
    • 118
    • 19
    • 10
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HSPD1 est non-conjugé
    Application
    • 194
    • 108
    • 99
    • 95
    • 68
    • 67
    • 27
    • 27
    • 25
    • 24
    • 12
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Recognizes amino acids 383-447. Recognizes a ~60 kDa protein, corresponding to the Molecular Mass of HSP60 on SDS-PAGE immunoblots.
    Attributs du produit
    Synonyms: HSP-60, HSPD1, Heat shock protein 60, Chaperonin 60, HuCHA60, GROEL, GroEL Homolog,CPN60, 60 kDa heat shock protein mitochondrial, 60 kDa chaperonin, Mitochondrialmatrix protein P1, P60 lymphocyte protein
    Purification
    Purified
    Immunogène
    Human Hsp60 produced through recombinant DNA methods in E. coli
    Clone
    LK2
    Isotype
    IgG1
    Top Product
    Discover our top product HSPD1 Anticorps primaire
  • Indications d'application
    Western blot (10): 0.25 μg/mL. Immunohistochemistry on Frozen Sections. This Clone is reported to work on Paraffin Sections. Flow Cytometry (12).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.1 mM PMSF and 50 % Glycerol.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Date de péremption
    12 months
  • Britti, Delaspre, Feldman, Osborne, Greif, Tamarit, Ros: "Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment." dans: Journal of cellular and molecular medicine, Vol. 22, Issue 2, pp. 834-848, (2019) (PubMed).

    Teigen, Orczewska, McLaughlin, OBrien: "Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback." dans: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 188, pp. 139-47, (2015) (PubMed).

    Kötter, Unger, Hamdani, Lang, Vorgerd, Nagel-Steger, Linke: "Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins." dans: The Journal of cell biology, Vol. 204, Issue 2, pp. 187-202, (2014) (PubMed).

    Surazynski, Miltyk, Prokop, Palka: "The effect of estrogen on prolidase-dependent regulation of HIF-1? expression in breast cancer cells." dans: Molecular and cellular biochemistry, Vol. 379, Issue 1-2, pp. 29-36, (2013) (PubMed).

    van der Lubbe, Lim, Meima, van Veghel, Rosenbaek, Mutig, Danser, Fenton, Zietse, Hoorn: "Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway." dans: Pflügers Archiv : European journal of physiology, Vol. 463, Issue 6, pp. 853-63, (2012) (PubMed).

    Hung, Li, Lee, Chang, Chien, Lee: "Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat." dans: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 111, Issue 10, pp. 550-9, (2012) (PubMed).

    Gao, Brosnan, Raine: "Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3548-56, (1995) (PubMed).

  • Antigène
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    Autre désignation
    HSP60 (HSPD1 Produits)
    Synonymes
    anticorps CPN60, anticorps GROEL, anticorps HLD4, anticorps HSP-60, anticorps HSP60, anticorps HSP65, anticorps HuCHA60, anticorps SPG13, anticorps chaperonin, anticorps cpn60, anticorps groel, anticorps hld4, anticorps hsp60, anticorps hsp65, anticorps spg13, anticorps 60kDa, anticorps Hsp60, anticorps 12, anticorps BP5, anticorps CG12101, anticorps Cpn60, anticorps Dmel\\CG12101, anticorps Dmhsp60, anticorps G62, anticorps HSP60A, anticorps Hsp60A, anticorps IEF16, anticorps Mmp-P1, anticorps SSP 7506, anticorps d-hsp60, anticorps hsp60A, anticorps l(1)10Ac, anticorps l(1)BP5, anticorps l(1)G8, anticorps l(1)HM21, anticorps l(1)L12, anticorps l(1)dp025, anticorps cb863, anticorps fa04a05, anticorps fb22d10, anticorps fi27b05, anticorps id:ibd2197, anticorps sb:cb144, anticorps wu:fa04a05, anticorps wu:fb22d10, anticorps wu:fi04a12, anticorps wu:fi27b05, anticorps MIF4, anticorps MNA2, anticorps mopA, anticorps groL, anticorps crpA, anticorps Hspd1-30p, anticorps heat shock protein family D (Hsp60) member 1, anticorps heat shock protein family D (Hsp60) member 1 S homeolog, anticorps 60 kDa heat shock protein, mitochondrial, anticorps heat shock protein 1 (chaperonin), anticorps Heat shock protein 60A, anticorps heat shock 60 protein 1, anticorps chaperone ATPase HSP60, anticorps molecular chaperone GroEL, anticorps thermosome subunit, anticorps chaperonin GroEL, anticorps mitochondrial chaperonin, anticorps heat shock protein family D member 1, anticorps HSPD1, anticorps hspd1.S, anticorps hspd1, anticorps LOC100414401, anticorps Hspd1, anticorps Hsp60A, anticorps HSP60, anticorps groEL, anticorps MMP_RS07785, anticorps groEl, anticorps LOC100136430
    Sujet
    In both prokaryotic and eukarytic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the best characterized chaperones. Hsp60, also known as Cpn60 or GroEl, is an abundant protein synthesized constitutively in the cell that is induced to a higher concentration after brief cell shock. It is present in many species and exhibits a remarkable sequence homology among various counterparts in bacteria, plants, and mammals with more than half of the residues identical between bacterial and mammalian Hsp60 (1-3). Whereas mammalian Hsp60 is localized within the mitochondria, plant Hsp60, or otherwise known as Rubisco-binding protein, is located in plant chloroplasts. It has been indicated that these proteins carry out a very important biological function due to the fact that Hsp60 is present in so many different species. The common characteristics of the Hsp60s from the divergent species are i) high abundance, ii) induction with environmental stress such as heat shock, iii) homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP, iv) ATPase activity and v) a role in folding and assembly of oligomeric protein structures (4). These similarities are supported by recent studies where the single-ring human mitochondrial homolog, Hsp60 with its co-chaperonin, Hsp10 were expressed in a E. coli strain, engineered so that the groE operon is under strict regulatory control. This study has demonstrated that expression of Hsp60-Hsp10 was able to carry out all essential in vivo functions of GroEL and its co-chaperonin, GroES (5). Another important function of Hsp60 and Hsp10 is their protective functions against infection and cellular stress. Hsp60 has however been linked to a number of autoimmune diseases, as well as Alzheimer's, coronary artery diseases, MS, and diabetes (6-9).Synonyms: 60 kDa chaperonin, 60 kDa heat shock protein mitochondrial, CPN60, Chaperonin 60, GROEL, GroEL Homolog, HSP-60, HSPD1, Heat shock protein 60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein
    ID gène
    3329
    UniProt
    P10809
    Pathways
    Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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