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Caspase 6 anticorps

CASP6 Reactivité: Humain WB Hôte: Souris Monoclonal MCH2 14 1-190 unconjugated
N° du produit ABIN264405
  • Antigène Voir toutes Caspase 6 (CASP6) Anticorps
    Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))
    Reactivité
    • 137
    • 78
    • 36
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 160
    • 9
    • 1
    Souris
    Clonalité
    • 149
    • 21
    Monoclonal
    Conjugué
    • 75
    • 16
    • 13
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp Caspase 6 est non-conjugé
    Application
    • 137
    • 68
    • 61
    • 41
    • 40
    • 30
    • 26
    • 17
    • 14
    • 13
    • 11
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB)
    Specificité
    Detects proenzyme form of human Caspase-6 by Western blot.
    Attributs du produit
    Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2
    Purification
    Purified
    Immunogène
    Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-6 protein and mouse myeloma cells. Genename: CASP6
    Clone
    MCH2 14 1-190
    Isotype
    IgG1
    Top Product
    Discover our top product CASP6 Anticorps primaire
  • Indications d'application
    Western Blot. Positive Control: MCF-7 cell lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.08 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: One year from despatch
    Date de péremption
    12 months
  • Antigène
    Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))
    Autre désignation
    Caspase-6 (CASP6 Produits)
    Synonymes
    anticorps xCaspase-6, anticorps mch2, anticorps caspase-6, anticorps zgc:112960, anticorps CASP6, anticorps casp6, anticorps Mch2, anticorps mCASP-6, anticorps MCH2, anticorps caspase 6 L homeolog, anticorps caspase 6, anticorps caspase 6, apoptosis-related cysteine peptidase, anticorps group XIIA secretory phospholipase A2, anticorps caspase-6, anticorps casp6.L, anticorps casp6, anticorps CASP6, anticorps CpipJ_CPIJ017008, anticorps Casp6
    Sujet
    Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
    ID gène
    839
    UniProt
    P55212
    Pathways
    Apoptose, Caspase Cascade in Apoptosis
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