KRT14 anticorps

N° du produit ABIN264414

Détail du produit anti-KRT14 anticorps

Antigène: KRT14 (Keratin 14 (KRT14))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KRT14 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody reacts specifically with Human Cytokeratin-14 (50 kDa) by Immunoblotting. Does not react with other Cytokeratins or other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: Cytokeratin-14, CK14, Keratin 14, K14, KRT14, Keratin Type I Cytoskeletal 14

Purification: Protein A/G Chromatography

Immunogène: Synthetic peptide conjugated to KLH corresponding to thecarboxy terminal sequence of human cytokeratin 14(KVVSTHEQVLRTKN)Genename: KRT14

Clone: DE-SPK14

Isotype: IgG2b

Information d'application

Indications d'application: Western Blot: Detects human cytokeratin 14 at 50 kDa. Immunohistochemistry (Frozen Sections): It provides a positive reaction on basal cells ofnon-keratinizing stratified epithelia, basal cells and suprabasal cells of the epidermis andgingiva, myoepithelial cells and squamous cell carcinomas. Not suitable for use in Paraffin embedded tissues.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur KRT14

Antigène: KRT14 (Keratin 14 (KRT14))

Autre désignation: Cytokeratin 14 (KRT14 Produits)

Synonymes: anticorps CK14, anticorps EBS3, anticorps EBS4, anticorps K14, anticorps NFJ, anticorps AI626930, anticorps Krt-1.14, anticorps Krt1-14, anticorps Ka14, anticorps ouro2, anticorps keratin 14, anticorps keratin 14, type I L homeolog, anticorps KRT14, anticorps Krt14, anticorps krt14.L

Sujet: Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Keratin 14 is a member of the keratin family, the most diverse group of intermediate filaments. It is usually found as a heterotetramer with two molecules of keratin 5, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. Keratin 14 has been studied as a prognostic marker in breast cancer.Synonyms: CK14, Cytokeratin-14, K14, KRT14, Keratin 14, Keratin Type I Cytoskeletal 14

ID gène: 3861

UniProt: P02533