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ADAM17 anticorps (C-Term)

ADAM17 Reactivité: Humain, Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN264994
  • Antigène Voir toutes ADAM17 Anticorps
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Épitope
    • 16
    • 13
    • 13
    • 8
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 807-823, C-Term
    Reactivité
    • 115
    • 54
    • 52
    • 4
    • 4
    • 4
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 100
    • 13
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 92
    • 25
    Polyclonal
    Conjugué
    • 54
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADAM17 est non-conjugé
    Application
    • 87
    • 53
    • 40
    • 15
    • 14
    • 14
    • 12
    • 11
    • 10
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Specificité
    This antibody Detects TACE (ADAM17/CD156b).
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product ADAM17 Anticorps primaire
  • Indications d'application
    Western Blot (0.25-1 μg/mL): Detects an approximately 130 kDa band in HeLa and Jurkatwhole cell lysate which may represent mature protein, precursor, and glycosylated TACE.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    DO NOT FREEZE!
    Stock
    4 °C
    Stockage commentaire
    The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
  • Antigène
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Autre désignation
    CD156b / ADAM17 (ADAM17 Produits)
    Synonymes
    anticorps ADAM18, anticorps CD156B, anticorps CSVP, anticorps NISBD, anticorps TACE, anticorps CD156b, anticorps Tace, anticorps adam17, anticorps si:dkey-81b15.2, anticorps adam18, anticorps cd156b, anticorps csvp, anticorps tace, anticorps fc20b01, anticorps wu:fc20b01, anticorps zgc:63886, anticorps ADAM metallopeptidase domain 17, anticorps a disintegrin and metallopeptidase domain 17, anticorps ADAM metallopeptidase domain 17b, anticorps ADAM metallopeptidase domain 17 L homeolog, anticorps ADAM metallopeptidase domain 17a, anticorps ADAM17, anticorps Adam17, anticorps adam17b, anticorps adam17.L, anticorps adam17a
    Sujet
    Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately (1-3). TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. (6)Synonyms: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme
    ID gène
    6868
    NCBI Accession
    NP_003174
    UniProt
    P78536
    Pathways
    Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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