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SH2D1A anticorps

SH2D1A Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN265020
  • Antigène Voir toutes SH2D1A Anticorps
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Reactivité
    • 50
    • 19
    • 19
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 46
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 49
    • 2
    Polyclonal
    Conjugué
    • 23
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SH2D1A est non-conjugé
    Application
    • 46
    • 20
    • 13
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Specificité
    This antibody reacts to SH2D1A.
    Purification
    Purified
    Immunogène
    Full-length recombinant SAP protein
    Isotype
    IgG
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    Discover our top product SH2D1A Anticorps primaire
  • Indications d'application
    Western Blot: 5 - 10 μg/mL. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline with 0.08 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • Antigène
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Autre désignation
    SH2D1A (SH2D1A Produits)
    Synonymes
    anticorps DSHP, anticorps EBVS, anticorps IMD5, anticorps LYP, anticorps MTCP1, anticorps SAP, anticorps SAP/SH2D1A, anticorps XLP, anticorps XLPD, anticorps RGD1562408, anticorps Gm686, anticorps SH2D1A, anticorps SH2 domain containing 1A, anticorps SH2D1A, anticorps Sh2d1a
    Sujet
    SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.Synonyms: DSHP, Duncan disease SH2-protein, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP
    ID gène
    4068
    NCBI Accession
    NP_001108409
    UniProt
    O60880
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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