LY96 anticorps (Middle Region)
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- Antigène Voir toutes LY96 Anticorps
- LY96 (Lymphocyte Antigen 96 (LY96))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp LY96 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purification
- Purified
- Immunogène
- Rabbit polyclonal MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.
- Isotype
- IgG
- Top Product
- Discover our top product LY96 Anticorps primaire
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- Indications d'application
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Western Blot: 0,5 - 1 μg/mL. Immunohistochemistry. Found in the liver and spleen, the secreted protein Lymphocyte antigen 96/MD-2ooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS),and with TLR2 in the response to cell wall components from Gram-positive andGram-negative bacteria.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- Phosphate buffered saline with 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Antigène
- LY96 (Lymphocyte Antigen 96 (LY96))
- Autre désignation
- MD-2 (LY96 Produits)
- Synonymes
- anticorps MD2, anticorps ESOP-1, anticorps MD-2, anticorps ly-96, anticorps Ly-96, anticorps Md2, anticorps lymphocyte antigen 96, anticorps LY96, anticorps Ly96
- Sujet
- MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1 - 3). TLRs are signaling molecules that recognize different pathogenassociated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2, e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2
- ID gène
- 9606
- UniProt
- Q9Y6Y9
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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