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IL4 Receptor anticorps

IL4R Reactivité: Souris ICFC, ELISA (Detection), ELISPOT (Detection) Hôte: Rat Monoclonal I015F8 unconjugated
N° du produit ABIN2664185
  • Antigène Voir toutes IL4 Receptor (IL4R) Anticorps
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Reactivité
    • 56
    • 42
    • 22
    Souris
    Hôte
    • 67
    • 12
    • 7
    • 2
    • 1
    Rat
    Clonalité
    • 72
    • 16
    • 1
    Monoclonal
    Conjugué
    • 48
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp IL4 Receptor est non-conjugé
    Application
    • 76
    • 28
    • 28
    • 15
    • 14
    • 13
    • 9
    • 9
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Intracellular Flow Cytometry (ICFC), ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection))
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    I015F8
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product IL4R Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Autre désignation
    CD124 (IL4R Produits)
    Synonymes
    anticorps IL4R, anticorps il-4ra, anticorps zgc:113063, anticorps CD124, anticorps IL-4RA, anticorps IL4RA, anticorps Il4ra, anticorps IL4, anticorps Il4r, anticorps interleukin 4 receptor, anticorps interleukin 4 receptor, tandem duplicate 1, anticorps interleukin 4 receptor, alpha, anticorps IL4R, anticorps il4r.1, anticorps Il4r, anticorps Il4ra
    Sujet
    CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Rα exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B cells, T cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind IL-4 and IL-13 and regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.
    Pathways
    Signalistation JAK/STAT, Positive Regulation of Immune Effector Process
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