Cathelicidin anticorps (AA 115-121)

N° du produit ABIN2666321

Détail du produit anti-Cathelicidin anticorps

Antigène: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Épitope: AA 115-121

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathelicidin est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: H7

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.

Stock: 4 °C

Stockage commentaire: Upon receipt, store undiluted between 2°C and 8°C.

Détails sur Cathelicidin

Antigène: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Autre désignation: CAP-18 (CAMP Produits)

Synonymes: anticorps CAP-18, anticorps CAP18, anticorps CRAMP, anticorps FALL-39, anticorps FALL39, anticorps LL37, anticorps CATH-2, anticorps Cnlp, anticorps Cramp, anticorps MCLP, anticorps CATH-B1, anticorps CATHB1, anticorps CATHL2, anticorps CATHL7, anticorps CAP11, anticorps cathelicidin antimicrobial peptide, anticorps CAMP, anticorps LOC100136187, anticorps LOC100136439, anticorps Camp

Sujet: Antimicrobial peptides (AMP) are effector molecules of the innate immune system with direct antimicrobioal and immunomodulatory effects. AMP are produced by epithelial and professional host defense cells such as macrophages or neutrophils. AMP directly inactivate microorganisms and, in addition, have diverse activities on various cell types. In mammals, peptides of the defensin and the cathelicidin families are found. hCAP-18 is the only cathelicidin present in humans. hCAP-18 is a 170 amino acid cathelicidin anti-microbial precursor protein that is proteolytically processed to yield the antibacterial peptide LL-37. The precursor hCAP-18 is found in the specific granules of neutrophils and is expressed in many immune and epithelial cells. Cathelicidin has an established role in host defense. In addition to their direct antimicrobial function, cathelicidin peptides are involved in the modulation of repair and tissue homeostasis, epithelial wound healing, chemoattraction of immune cells, and release of inflammatory mediators from epithelial cells. Recent studies also found that LL-37 significantly regulates endocytic capacity, modifies expression of phagocytic receptors, increases secretion of Th1-inducing cytokines of dendritic cells (DC) generated from blood monocytes, and modulates the response of monocytes and DC to toll like receptor (TLR)-ligands. Moreover LL-37 also modulates the response of neutrophils to bacterial activation.

Pathways: Cellular Response to Molecule of Bacterial Origin