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CD137 anticorps (Biotin)

TNFRSF9 Reactivité: Humain ELISA Hôte: Souris Monoclonal 4B4 Biotin
N° du produit ABIN2688963
  • Antigène Voir toutes CD137 (TNFRSF9) Anticorps
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Reactivité
    • 97
    • 42
    • 26
    • 8
    • 4
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 41
    • 12
    • 11
    • 5
    • 1
    Souris
    Clonalité
    • 63
    • 47
    • 3
    Monoclonal
    Conjugué
    • 60
    • 14
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD137 est conjugé à/à la Biotin
    Application
    • 73
    • 59
    • 54
    • 15
    • 14
    • 12
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA
    Marque
    BD Pharmingen™
    Attributs du produit
    Reacts with 4-1BB, a 30 kDa glycoprotein expressed on activated T cells. 4-1BB can be detected on Con A or PHA-stimulated peripheral blood T cells (CD4+ and CD8+) and on CEM cells (human T-cell leukemia) following 2 day PMA and ionomycin stimulation, but not on resting T cells. 4-1BB is reported to be a participant in T-cell activation, being responsible for rescuing T cells from activation-induced apoptosis, upregulation of Th1-type, T-helper cells, downregulation of Th2-type cytokine production, and induction of cell adhesion to fibronectin.

    BD Pharmingen™ Biotin Anti-Human CD137 - Biotin - Clone 4B4-1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    4B4
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TNFRSF9 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Kim, Broxmeyer: "Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells." dans: Journal of hematotherapy & stem cell research, Vol. 10, Issue 4, pp. 441-9, (2001) (PubMed).

    Michel, Schwarz: "Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes." dans: Cytokine, Vol. 12, Issue 6, pp. 742-6, (2000) (PubMed).

    Vinay, Kwon: "Role of 4-1BB in immune responses." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 481-9, (1999) (PubMed).

    Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." dans: Nature medicine, Vol. 3, Issue 6, pp. 682-5, (1997) (PubMed).

  • Antigène
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Autre désignation
    CD137 (TNFRSF9 Produits)
    Synonymes
    anticorps TNFRSF9, anticorps zgc:136557, anticorps 4-1BB, anticorps CD137, anticorps CDw137, anticorps ILA, anticorps A930040I11Rik, anticorps AA408498, anticorps AI325004, anticorps Cd137, anticorps Ly63, anticorps tumor necrosis factor receptor superfamily member 9, anticorps TNF receptor superfamily member 9, anticorps tumor necrosis factor receptor superfamily, member 9a, anticorps tumor necrosis factor receptor superfamily, member 9, anticorps TNFRSF9, anticorps tnfrsf9a, anticorps Tnfrsf9
    Sujet
    Synonyms: 4-1BB
    Pathways
    Cancer Immune Checkpoints
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