Reacts with 4-1BB, a 30 kDa glycoprotein expressed on activated T cells. 4-1BB can be detected on Con A or PHA-stimulated peripheral blood T cells (CD4+ and CD8+) and on CEM cells (human T-cell leukemia) following 2 day PMA and ionomycin stimulation, but not on resting T cells. 4-1BB is reported to be a participant in T-cell activation, being responsible for rescuing T cells from activation-induced apoptosis, upregulation of Th1-type, T-helper cells, downregulation of Th2-type cytokine production, and induction of cell adhesion to fibronectin.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Kim, Broxmeyer: "Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells." dans: Journal of hematotherapy & stem cell research, Vol. 10, Issue 4, pp. 441-9, (2001) (PubMed).
Michel, Schwarz: "Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes." dans: Cytokine, Vol. 12, Issue 6, pp. 742-6, (2000) (PubMed).
Vinay, Kwon: "Role of 4-1BB in immune responses." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 481-9, (1999) (PubMed).
Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." dans: Nature medicine, Vol. 3, Issue 6, pp. 682-5, (1997) (PubMed).
Antigène
CD137 (TNFRSF9)
(Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))