Reacts with a type II membrane protein known as 4-1BB ligand. This molecule belongs to the TNF superfamily. It has been reported to have costimulatory function on activated T cells. Reports suggest that stimulation of activated T cells via 4-1BB ligand does not require the presence of other costimulatory molecules, including CD28. Some studies have reported human 4-1BB ligand to be expressed preferentially on primary B cells and B-cell lines. C65-485 antibody is able to react with recombinant human 4-1BB ligand (rh4-1BBL) bound to CD137 (4-1BB receptor) expressed on PHA-stimulated PBMC. Profile of Hut-78 cell line analzed by flow cytometry
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C.
Melero, Bach, Hellström, Aruffo, Mittler, Chen: "Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway." dans: European journal of immunology, Vol. 28, Issue 3, pp. 1116-21, (1998) (PubMed).
Chu, DeBenedette, Stiernholm, Barber, Watts: "Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 7, pp. 3081-9, (1997) (PubMed).
DeBenedette, Shahinian, Mak, Watts: "Costimulation of CD28- T lymphocytes by 4-1BB ligand." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 2, pp. 551-9, (1997) (PubMed).
Zhou, Kim, Hurtado, Lee, Kim, Pollok, Kwon: "Characterization of human homologue of 4-1BB and its ligand." dans: Immunology letters, Vol. 45, Issue 1-2, pp. 67-73, (1995) (PubMed).
Antigène
TNFSF9
(Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))