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TOP2B anticorps

TOP2B Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN271965
  • Antigène Voir toutes TOP2B Anticorps
    TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
    Reactivité
    • 49
    • 18
    • 17
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Humain, Souris
    Hôte
    • 46
    • 4
    Lapin
    Clonalité
    • 46
    • 3
    Polyclonal
    Conjugué
    • 25
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TOP2B est non-conjugé
    Application
    • 21
    • 15
    • 14
    • 13
    • 13
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of Topoisomerase II β protein. (region surrounding Ala32)
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product TOP2B Anticorps primaire
  • Indications d'application
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
    Autre désignation
    TOP2B (TOP2B Produits)
    Synonymes
    anticorps TOP2B, anticorps D230016L12Rik, anticorps Top-2, anticorps TOPIIB, anticorps top2beta, anticorps DNA topoisomerase II beta, anticorps topoisomerase (DNA) II beta, anticorps microRNA 4442, anticorps TOP2B, anticorps Top2b, anticorps MIR4442
    Sujet
    Topoisomerases are nuclear enzymes involved in a variety of cellular activities such as chromosome condensation, DNA replication, transcription, recombination and segregation at mitosis. Human topoisomerase I is a 100kD protein capable of relaxing positively and negatively supercoiled DNA by performing a transient single stranded nick which is then religated at the end of the reaction. It has been shown that the enzyme is located in regions of the genome that are undergoing active RNA synthesis, where it probably reduces superhelical stresses in the DNA, enabling RNA polymerase to function properly. Both DNA topoisomerases I and II have been found to be targets of autoantibodies in the sera of patients with certain autoimmune diseases such as systemic lupus erythematosus and also of some anti tumor drugs and antibiotics. Elevated levels of DNA topoisomerase I, detected by transfer assays, have been demonstrated in colorectal tumors compared with normal colon mucosa as a result of increased transcription or mRNA stability.Synonyms: DNA topoisomerase 2-beta, DNA topoisomerase II beta isozyme
    Poids moléculaire
    approx. 183 kDa
    ID gène
    7155
    NCBI Accession
    NP_001059
    UniProt
    Q02880
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