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CD137 anticorps (PE)

TNFRSF9 Reactivité: Humain, Non-Human Primate FACS Hôte: Souris Monoclonal 4B4-1 PE
N° du produit ABIN2749106
  • Antigène Voir toutes CD137 (TNFRSF9) Anticorps
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Reactivité
    • 96
    • 42
    • 26
    • 8
    • 3
    • 1
    • 1
    Humain, Non-Human Primate
    Hôte
    • 45
    • 40
    • 12
    • 11
    • 5
    • 1
    Souris
    Clonalité
    • 62
    • 47
    • 3
    Monoclonal
    Conjugué
    • 60
    • 14
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD137 est conjugé à/à la PE
    Application
    • 72
    • 59
    • 54
    • 15
    • 14
    • 12
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Recombinant human CD137 ectodomain
    Clone
    4B4-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TNFRSF9 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Yi, Zhao, Wang, Dai, Hellström, Hellström, Zhang: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." dans: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).

    Bellarosa, Bressan, Bigioni, Parlani, Maggi, Binaschi: "SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line." dans: International journal of oncology, Vol. 41, Issue 4, pp. 1486-94, (2013) (PubMed).

    Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." dans: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, (2012) (PubMed).

    Chan, Voskens, Lin, Schindler, Azimzadeh, Wang, Taylor, Strome, Schulze: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." dans: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, (2009) (PubMed).

  • Antigène
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Autre désignation
    CD137 / 4-1BB (TNFRSF9 Produits)
    Synonymes
    anticorps TNFRSF9, anticorps zgc:136557, anticorps 4-1BB, anticorps CD137, anticorps CDw137, anticorps ILA, anticorps A930040I11Rik, anticorps AA408498, anticorps AI325004, anticorps Cd137, anticorps Ly63, anticorps tumor necrosis factor receptor superfamily member 9, anticorps TNF receptor superfamily member 9, anticorps tumor necrosis factor receptor superfamily, member 9a, anticorps tumor necrosis factor receptor superfamily, member 9, anticorps TNFRSF9, anticorps tnfrsf9a, anticorps Tnfrsf9
    Sujet
    TNF receptor superfamily member 9,CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.,TNFRSF9, 41BB, 4-1BB, MGC2172
    ID gène
    3604
    UniProt
    Q07011
    Pathways
    Cancer Immune Checkpoints
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