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MRVI1 anticorps (N-Term)

MRVI1 Reactivité: Humain, Cheval, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2773963
  • Antigène Voir toutes MRVI1 Anticorps
    MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
    Épitope
    • 1
    • 1
    N-Term
    Reactivité
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Cheval, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Rat
    Hôte
    • 3
    Lapin
    Clonalité
    • 3
    Polyclonal
    Conjugué
    • 3
    Cet anticorp MRVI1 est non-conjugé
    Application
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1
    Top Product
    Discover our top product MRVI1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeat freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
    Autre désignation
    MRVI1 (MRVI1 Produits)
    Synonymes
    anticorps BB115629, anticorps Irag, anticorps Ris1, anticorps IRAG, anticorps JAW1L, anticorps MRV integration site 1, anticorps murine retrovirus integration site 1 homolog, anticorps Mrvi1, anticorps MRVI1
    Sujet
    This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
    Protein Interaction Partner: MME, PRKG1, ITPR1,
    Protein Size: 803
    Poids moléculaire
    88 kDa
    ID gène
    10335
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