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Leptin anticorps (Middle Region)

LEP Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Chévre, Lapin, Mouton, Porc WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776944
  • Antigène Voir toutes Leptin (LEP) Anticorps
    Leptin (LEP)
    Épitope
    • 25
    • 16
    • 15
    • 15
    • 12
    • 11
    • 10
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 126
    • 74
    • 72
    • 11
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Chévre, Lapin, Mouton, Porc
    Hôte
    • 178
    • 24
    • 6
    • 5
    • 2
    Lapin
    Clonalité
    • 189
    • 25
    Polyclonal
    Conjugué
    • 107
    • 26
    • 17
    • 9
    • 8
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Cet anticorp Leptin est non-conjugé
    Application
    • 135
    • 85
    • 66
    • 39
    • 39
    • 38
    • 32
    • 30
    • 25
    • 21
    • 16
    • 11
    • 11
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    LHVLAFSKSC HLPWASGLET LDSLGGVLEA SGYSTEVVAL SRLQGSLQDM
    Homologie
    Cow: 100%, Dog: 86%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against LEP. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human LEP
    Top Product
    Discover our top product LEP Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 167 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Leptin (LEP)
    Autre désignation
    LEP (LEP Produits)
    Synonymes
    anticorps ob, anticorps obese, anticorps LEPD, anticorps OB, anticorps OBS, anticorps leptin, anticorps Lep, anticorps LEP, anticorps lep
    Sujet
    LEP is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: OB, OBS
    Protein Interaction Partner: Hk3, SIGLEC6, GHRL, LEPR, UCN, PRKAA2, CLU, CRP, A2M, STAT3,
    Protein Size: 167
    Poids moléculaire
    16 kDa
    ID gène
    3952
    NCBI Accession
    NM_000230, NP_000221
    UniProt
    P41159
    Pathways
    Signalistation JAK/STAT, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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