BDNF anticorps (Middle Region)
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- Antigène Voir toutes BDNF Anticorps
- BDNF (Brain-Derived Neurotrophic Factor (BDNF))
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Épitope
- Middle Region
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Reactivité
- Humain, Rat, Souris, Porc, Lapin, Cheval, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BDNF est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- EWVTAADKKT AVDMSGGTVT VLEKVPVSKG QLKQYFYETK CNPMGYTKEG
- Homologie
- Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against BDNF. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human BDNF
- Top Product
- Discover our top product BDNF Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 247 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain." dans: Developmental neuroscience, Vol. 38, Issue 5, pp. 365-374, (2017) (PubMed).
: "Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model." dans: Developmental neuroscience, Vol. 38, Issue 5, pp. 354-364, (2016) (PubMed).
: "Sex differences and estrogen regulation of BDNF gene expression, but not propeptide content, in the developing hippocampus." dans: Journal of neuroscience research, Vol. 95, Issue 1-2, pp. 345-354, (2016) (PubMed).
: "TrkB/BDNF signalling patterns the sympathetic nervous system." dans: Nature communications, Vol. 6, pp. 8281, (2015) (PubMed).
: "Epigenetic inheritance of a cocaine-resistance phenotype." dans: Nature neuroscience, Vol. 16, Issue 1, pp. 42-7, (2012) (PubMed).
: "Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 38, pp. 13400-11, (2011) (PubMed).
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Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain." dans: Developmental neuroscience, Vol. 38, Issue 5, pp. 365-374, (2017) (PubMed).
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- Antigène
- BDNF (Brain-Derived Neurotrophic Factor (BDNF))
- Autre désignation
- BDNF (BDNF Produits)
- Synonymes
- anticorps ANON2, anticorps BULN2, anticorps bdnf-A, anticorps BDNF, anticorps bdnf, anticorps brain derived neurotrophic factor, anticorps brain-derived neurotrophic factor, anticorps brain-derived neurotrophic factor L homeolog, anticorps brain-derived neurotrophic factor S homeolog, anticorps BDNF, anticorps Bdnf, anticorps bdnf, anticorps bdnf.L, anticorps bdnf.S
- Sujet
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BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression BDNF is reduced in both Alzheimer's and Huntington disease patients. BDNF may play a role in the regulation of stress response and in the biology of mood disorders.The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
Alias Symbols: MGC34632
Protein Interaction Partner: UBC, AGO3, INPP5K, F11R, JUNB, APP, ELAVL1, Ntrk2, CADPS2, MBTPS1, SORT1, NOS3, NTF4, NTF3, ESR1, NCAM1, CPE, BDNF,
Protein Size: 247 - Poids moléculaire
- 27 kDa
- ID gène
- 627
- NCBI Accession
- NM_001709, NP_001700
- UniProt
- P23560
- Pathways
- Signalisation RTK, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
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