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MXI1 anticorps (Middle Region)

MXI1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2777279
  • Antigène Voir toutes MXI1 Anticorps
    MXI1 (MAX Interactor 1 (MXI1))
    Épitope
    • 8
    • 7
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 34
    • 32
    • 16
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae
    Hôte
    • 40
    • 4
    • 2
    Lapin
    Clonalité
    • 42
    • 4
    Polyclonal
    Conjugué
    • 25
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MXI1 est non-conjugé
    Application
    • 32
    • 22
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    LNKAKAHIKK LEEAERKSQH QLENLEREQR FLKWRLEQLQ GPQEMERIRM
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against MXI1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human MXI1
    Top Product
    Discover our top product MXI1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 295 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MXI1 (MAX Interactor 1 (MXI1))
    Autre désignation
    MXI1 (MXI1 Produits)
    Synonymes
    anticorps mxi, anticorps mad2, anticorps mxd2, anticorps xmxi1, anticorps MGC89544, anticorps MXI1, anticorps etID309773.22, anticorps fb16b12, anticorps fb55f03, anticorps wu:fb16b12, anticorps wu:fb55f03, anticorps wu:fd06a08, anticorps wu:fz74f10, anticorps ENSMUSG00000067085, anticorps Gm10197, anticorps Mad2, anticorps bHLHc11, anticorps MXI-WR, anticorps MAD2, anticorps MXD2, anticorps MXI, anticorps MAX interactor 1, dimerization protein, anticorps max interactor 1, dimerization protein, anticorps MAX interactor 1, dimerization protein L homeolog, anticorps mxi1, anticorps MXI1, anticorps Mxi1, anticorps mxi1.L
    Sujet
    Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors.Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
    Alias Symbols: MAD2, MGC43220, MXD2, MXI, bHLHc11
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-5, KRTAP10-9, KRTAP10-7, KRT40, RPL23AP32, CALCOCO2, MAX, ENTPD5, UBC, APP, CDC20, BUB1B, SIN3B, SIN3A, SMC3, MYC,
    Protein Size: 295
    Poids moléculaire
    26 kDa
    ID gène
    4601
    NCBI Accession
    NM_130439, NP_569157
    UniProt
    P50539
    Pathways
    Maintenance of Protein Location
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