PDPK1 anticorps (3-phosphoinositide Dependent Protein Kinase-1) (Middle Region)

Details for Product anti-PDPK1 Antibody No. ABIN2777432, Fournisseur: Connectez-vous pour afficher
Antigène
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • zgc:153787
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase-1a
  • 3-phosphoinositide-dependent protein kinase 1
  • Phosphoinositide-dependent kinase 1
  • Protein PDK-1
  • PDPK1
  • pdpk1
  • Pdpk1
  • pdpk1a
  • Pdk1
  • pdk-1
Épitope
Middle Region
60
35
32
27
27
26
18
17
15
15
15
15
8
7
6
6
6
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Lapin, Rat (Rattus), Yeast
465
220
220
19
13
11
10
10
6
4
3
3
2
1
1
1
1
1
1
Hôte
Lapin
383
73
16
Clonalité
Polyclonal
Conjugué
Cet anticorp PDPK1 est non-conjugé
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
6
5
5
4
4
3
3
3
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
313
158
102
91
67
66
40
31
22
10
7
5
3
2
1
Options
Fournisseur
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Supplier Product No.
Connectez-vous pour afficher
Immunogène The immunogen is a synthetic peptide directed towards the middle region of human PDK1
Blocking Peptide Blocking peptide for this product available: ABIN981538
Séquence ATMEHHANRG VYPPIQVHVT LGNEDLTVKM SDRGGGVPLR KIDRLFNYMY
Homologie Cow: 86%, Dog: 79%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%, Yeast: 90%
Attributs du produit This is a rabbit polyclonal antibody against PDK1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Autre désignation PDK1 (PDPK1 Antibody Extrait)
Sujet Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: EGFR, PDK1, KAT2B, USP4, UBC, MYC, XRCC6, SGK1, DLAT, RPS6KB1, PDK2, PDHA1, YWHAQ, RPTOR, RALGDS, PKN2, PKN1, MTOR, AKT1,
Protein Size: 436
Poids moléculaire 47 kDa
ID gène 5163
NCBI Accession NM_002610, NP_002601
UniProt Q15118
Domaine de recherche Signaling, Cytoskeleton, Microfilaments, Kinases/Phosphatases
Pathways Signalisation PI3K-Akt, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 436 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) antibody (ABIN2777432) Host: Rabbit Target Name: CHAD Sample Type: Human Adult Placenta Antibody Dilution: 1...
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) antibody (ABIN2777432) Host: Rabbit Target Name: PDK1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) antibody (ABIN2777432) Host: Rabbit Target Name: PDK2 Sample Type: Human Jurkat Antibody Dilution: 1.0ug/ml ...
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) antibody (ABIN2777432) WB Suggested Anti-PDK1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positiv...
Background publications Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: "Amlodipine inhibits cell proliferation via PKD1-related pathway." dans: Biochemical and biophysical research communications, Vol. 369, Issue 2, pp. 376-81, 2008 (PubMed).

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