PCCA anticorps (N-Term)

N° du produit ABIN2777736

Détail du produit anti-PCCA anticorps

Antigène: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval, Chien, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCCA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LYYSRQCLMV SRNLGSVGYD PNEKTFDKIL VANRGEIACR VIRTCKKMGI

Homologie: Cow: 86%, Dog: 86%, Horse: 83%, Human: 100%, Mouse: 77%, Pig: 86%, Rabbit: 86%, Rat: 86%, Zebrafish: 75%

Attributs du produit: This is a rabbit polyclonal antibody against PCCA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PCCA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 728 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PCCA (ABIN2777736)

Rincón, Aguado, Desviat, Sánchez-Alcudia, Ugarte, Pérez: "Propionic and methylmalonic acidemia: antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA." dans: American journal of human genetics, Vol. 81, Issue 6, pp. 1262-70, (2011) (PubMed).

Détails sur PCCA

Antigène: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Autre désignation: PCCA (PCCA Produits)

Synonymes: anticorps pcca, anticorps zgc:66359, anticorps C79630, anticorps wu:fb92g02, anticorps zgc:100925, anticorps propionyl-CoA carboxylase alpha subunit, anticorps propionyl-COA carboxylase alpha chain, mitochondrial, anticorps propionyl-CoA carboxylase alpha chain, anticorps zinc finger CCCH-type containing 13, anticorps propionyl-Coenzyme A carboxylase, alpha polypeptide, anticorps propionyl CoA carboxylase, alpha polypeptide, anticorps propionyl-CoA carboxylase alpha subunit L homeolog, anticorps PCCA, anticorps Pcca, anticorps BMEI0800, anticorps pccA, anticorps NRI_0781, anticorps zc3h13, anticorps pcca, anticorps pcca.L

Sujet: PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA is the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia.The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: -
Protein Interaction Partner: HUWE1, PARK2, IFIT1, UBE2N, UBC, EBNA-LP, PCCB,
Protein Size: 728

Poids moléculaire: 75 kDa

ID gène: 5095

NCBI Accession: NM_000282, NP_000273

UniProt: Q8WXQ7

Pathways: Monocarboxylic Acid Catabolic Process