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Cyclin D1 anticorps (N-Term)

CCND1 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Lapin, Chien, Cobaye, Porc WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2777893
  • Antigène Voir toutes Cyclin D1 (CCND1) Anticorps
    Cyclin D1 (CCND1)
    Épitope
    • 22
    • 22
    • 16
    • 16
    • 13
    • 11
    • 9
    • 9
    • 7
    • 7
    • 7
    • 7
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    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    N-Term
    Reactivité
    • 245
    • 130
    • 124
    • 37
    • 19
    • 18
    • 17
    • 10
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Boeuf (Vache), Lapin, Chien, Cobaye, Porc
    Hôte
    • 210
    • 59
    • 1
    Lapin
    Clonalité
    • 198
    • 70
    Polyclonal
    Conjugué
    • 121
    • 29
    • 21
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cyclin D1 est non-conjugé
    Application
    • 206
    • 90
    • 72
    • 68
    • 42
    • 34
    • 27
    • 27
    • 25
    • 22
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    • 14
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    KCEEEVFPLA MNYLDRFLSL EPVKKSRLQL LGATCMFVAS KMKETIPLTA
    Homologie
    Cow: 100%, Dog: 92%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against CCND1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human CCND1
    Top Product
    Discover our top product CCND1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 295 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Cyclin D1 (CCND1)
    Autre désignation
    CCND1 (CCND1 Produits)
    Synonymes
    anticorps BCL1, anticorps D11S287E, anticorps PRAD1, anticorps U21B31, anticorps AI327039, anticorps CycD1, anticorps Cyl-1, anticorps bcl-1, anticorps cD1, anticorps cb161, anticorps cycd1, anticorps etID37810.7, anticorps fb52e01, anticorps fc45c08, anticorps fc83a12, anticorps id:ibd1198, anticorps wu:fb52e01, anticorps wu:fc45c08, anticorps wu:fc83a12, anticorps ccnd1b, anticorps prad1, anticorps ccnd1, anticorps ccnd1a, anticorps bcl1, anticorps d11s287e, anticorps u21b31, anticorps CCND1, anticorps cyclin D1, anticorps cyclin D1 S homeolog, anticorps cyclin D1 L homeolog, anticorps CCND1, anticorps Ccnd1, anticorps ccnd1, anticorps ccnd1.S, anticorps ccnd1.L
    Sujet
    CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: BCL1, D11S287E, PRAD1, U21B31
    Protein Interaction Partner: CDKN1B, CDKN1A, CDK4, RELA, FBXO31, UBC, FBXO4, CAMK1, TP73, RB1, CDK2, HSPA8, POLR1B, MCM10, ORC4, LPL, BRINP1, CDK6, RABEP1, CARD11, CUL1, RBL2, UBTF, CCND1, ATF2, CDKN2A, FBXW8, BTRC, PPP1CC, PPP1CB, PSMA6, ITLN1, MCM7, MCM6, MCM3, MCM2, ELAVL1, PCNA,
    Protein Size: 295
    Poids moléculaire
    34 kDa
    ID gène
    595
    NCBI Accession
    NM_053056, NP_444284
    UniProt
    P24385
    Pathways
    Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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