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p53 anticorps (N-Term)

TP53 Reactivité: Humain WB, ELISA, ChIP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779330
  • Antigène Voir toutes p53 (TP53) Anticorps
    p53 (TP53) (Tumor Protein P53 (TP53))
    Épitope
    • 51
    • 41
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    • 32
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    • 28
    • 25
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    N-Term
    Reactivité
    • 901
    • 273
    • 223
    • 113
    • 48
    • 35
    • 33
    • 19
    • 10
    • 8
    • 8
    • 6
    • 4
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    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 678
    • 239
    • 6
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 612
    • 314
    • 1
    Polyclonal
    Conjugué
    • 519
    • 49
    • 40
    • 26
    • 25
    • 25
    • 24
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    • 13
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    • 2
    • 2
    • 2
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp p53 est non-conjugé
    Application
    • 726
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    • 1
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    • 1
    Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP)
    Séquence
    EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE
    Homologie
    Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against TP53. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human TP53
    Top Product
    Discover our top product TP53 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 393 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    p53 (TP53) (Tumor Protein P53 (TP53))
    Autre désignation
    TP53 (TP53 Produits)
    Synonymes
    anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L
    Sujet
    TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
    Alias Symbols: LFS1, TRP53, p53
    Protein Size: 393
    Poids moléculaire
    44 kDa
    ID gène
    7157
    NCBI Accession
    NM_000546, NP_000537
    UniProt
    P04637
    Pathways
    Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg
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