SIRT6 anticorps (Middle Region)

N° du produit ABIN2779624

Détail du produit anti-SIRT6 anticorps

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Épitope: Middle Region

Reactivité: Humain, Rat, Chien, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Séquence: TRINGSIPAG PKQEPCAQHN GSEPASPKRE RPTSPAPHRP PKRVKAKAVP

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against SIRT6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SIRT6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 355 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIRT6 (ABIN2779624)

Wajapeyee, Malonia, Palakurthy, Green: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." dans: Genes & development, Vol. 27, Issue 20, pp. 2221-6, (2013) (PubMed).

Gazin, Wajapeyee, Gobeil, Virbasius, Green: "An elaborate pathway required for Ras-mediated epigenetic silencing." dans: Nature, Vol. 449, Issue 7165, pp. 1073-7, (2007) (PubMed).

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: SIRT6 (SIRT6 Produits)

Synonymes: anticorps 2810449N18Rik, anticorps AI043036, anticorps Sir2l6, anticorps SIR2L6, anticorps zgc:86729, anticorps sirtuin 6, anticorps sirtuin 6 S homeolog, anticorps Sirt6, anticorps SIRT6, anticorps sirt6.S, anticorps sirt6

Sujet: SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: SIR2L6
Protein Interaction Partner: UBC, MDM2, AKT1, STUB1, SKP2, ABCF2, FAF1, VIM, UBE2D1, CHD3, NR0B2, tat, CCNDBP1, RELA, XRCC5, PRKDC, XRCC6, ELF5,
Protein Size: 355

Poids moléculaire: 39 kDa

ID gène: 51548

NCBI Accession: NM_016539, NP_057623

UniProt: Q8N6T7