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AIRE anticorps (N-Term)

AIRE Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779777
  • Antigène Voir toutes AIRE Anticorps
    AIRE (Autoimmune Regulator (AIRE))
    Épitope
    • 10
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 51
    • 22
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye
    Hôte
    • 46
    • 7
    • 1
    Lapin
    Clonalité
    • 53
    Polyclonal
    Conjugué
    • 38
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AIRE est non-conjugé
    Application
    • 39
    • 25
    • 19
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    HRTEIAVAVD SAFPLLHALA DHDVVPEDKF QETLHLKEKE GCPQAFHALL
    Homologie
    Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
    Top Product
    Discover our top product AIRE Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 545 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    AIRE (Autoimmune Regulator (AIRE))
    Autre désignation
    AIRE (AIRE Produits)
    Synonymes
    anticorps AIRE1, anticorps APECED, anticorps APS1, anticorps APSI, anticorps PGA1, anticorps autoimmune regulator, anticorps autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), anticorps AaeL_AAEL013794, anticorps CpipJ_CPIJ001208, anticorps CpipJ_CPIJ001209, anticorps AIRE, anticorps Aire
    Sujet
    The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
    Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
    Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
    Protein Size: 545
    Poids moléculaire
    58 kDa
    ID gène
    326
    NCBI Accession
    NM_000383, NP_000374
    UniProt
    O43918
    Pathways
    Chromatin Binding
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