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SMAD1 anticorps (C-Term)

SMAD1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye, Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780720
  • Antigène Voir toutes SMAD1 Anticorps
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Épitope
    • 23
    • 20
    • 18
    • 15
    • 14
    • 13
    • 11
    • 10
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 206
    • 128
    • 93
    • 9
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye, Lapin
    Hôte
    • 206
    • 16
    Lapin
    Clonalité
    • 196
    • 27
    Polyclonal
    Conjugué
    • 104
    • 20
    • 13
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    Cet anticorp SMAD1 est non-conjugé
    Application
    • 176
    • 91
    • 53
    • 52
    • 44
    • 32
    • 25
    • 19
    • 12
    • 11
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    FVKGWGAEYH RQDVTSTPCW IEIHLHGPLQ WLDKVLTQMG SPHNPISSVS
    Specificité
    Expected to react with SMAD1 and SMAD9 (100 % homology) and SMAD5 (93 % homology).
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against SMAD1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human SMAD1
    Top Product
    Discover our top product SMAD1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 465 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Autre désignation
    SMAD1 (SMAD1 Produits)
    Synonymes
    anticorps MLP, anticorps Xmad1, anticorps Xsmad1, anticorps bsp1, anticorps jv4-1, anticorps jv41, anticorps madh1, anticorps madr1, anticorps smad-1, anticorps MADH1, anticorps fb39h09, anticorps wu:fb39h09, anticorps wu:fb97e04, anticorps 2/23, anticorps CG12399, anticorps Dmel\\CG12399, anticorps E(zen)2, anticorps En(vvl), anticorps MAD, anticorps Mat, anticorps P-Mad, anticorps P-mad, anticorps PMad, anticorps Smad, anticorps Smad1, anticorps apg, anticorps c28, anticorps dMAD, anticorps dMad, anticorps l(2)K00237, anticorps l(2)k00237, anticorps mad, anticorps p-Mad, anticorps pMAD, anticorps pMad, anticorps pSmad, anticorps BSP-1, anticorps BSP1, anticorps JV4-1, anticorps JV41, anticorps MADR1, anticorps AI528653, anticorps Madh1, anticorps Madr1, anticorps Mlp1, anticorps MusMLP, anticorps smad1, anticorps xmad, anticorps SMAD family member 1, anticorps Mothers against dpp, anticorps SMAD family member 1 L homeolog, anticorps smad1, anticorps SMAD1, anticorps Mad, anticorps Smad1, anticorps smad1.L
    Sujet
    SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
    Alias Symbols: BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1
    Protein Interaction Partner: HDAC1, SMURF1, WDR77, AR, UBC, ACVRL1, SMAD4, LEMD3, MAPK1, GSK3B, ZNF521, ZNF423, AKR1B1, AP2A2, PIAS4, ZDHHC3, HBP1, IRF2BP1, SF3B1, MGA, ZNF510, ICK, GMEB1, ZEB2, PUM1, PIGQ, PIAS1, TTF2, KMT2D, ZNF76, XPC, TTF1, SOX5, SNRNP70, SMAD3, SMAD2, SMAD1, INP
    Protein Size: 465
    Poids moléculaire
    51 kDa
    ID gène
    4086
    NCBI Accession
    NM_005900, NP_005891
    UniProt
    Q15797
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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