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AGT anticorps (N-Term)

AGT Reactivité: Humain, Rat, Souris, Chien, Cheval, Mouton, Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2781494
  • Antigène Voir toutes AGT Anticorps
    AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))
    Épitope
    • 16
    • 15
    • 12
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 120
    • 55
    • 54
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien, Cheval, Mouton, Lapin
    Hôte
    • 107
    • 36
    • 1
    Lapin
    Clonalité
    • 100
    • 44
    Polyclonal
    Conjugué
    • 74
    • 19
    • 12
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp AGT est non-conjugé
    Application
    • 110
    • 46
    • 36
    • 27
    • 27
    • 20
    • 14
    • 14
    • 10
    • 9
    • 8
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    IHPFHLVIHN ESTCEQLAKA NAGKPKDPTF IPAPIQAKTS PVDEKALQDQ
    Homologie
    Dog: 92%, Horse: 85%, Human: 100%, Mouse: 86%, Rabbit: 92%, Rat: 93%, Sheep: 77%
    Attributs du produit
    This is a rabbit polyclonal antibody against AGT. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human AGT
    Top Product
    Discover our top product AGT Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 485 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))
    Autre désignation
    AGT (AGT Produits)
    Synonymes
    anticorps ANHU, anticorps SERPINA8, anticorps AI265500, anticorps AngI, anticorps AngII, anticorps Aogen, anticorps Serpina8, anticorps ANRT, anticorps Ang, anticorps PAT, anticorps wu:fb62f06, anticorps wu:fj87b02, anticorps zgc:111892, anticorps AGT, anticorps angt, anticorps ANGT, anticorps angiotensinogen, anticorps angiotensinogen (serpin peptidase inhibitor, clade A, member 8), anticorps AGT, anticorps Agt, anticorps agt
    Sujet
    AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: ANHU, SERPINA8
    Protein Interaction Partner: ATP6AP2, REN, ACE, ACE2, MME, ECE1, GSDMB, ITSN2, TP53, GRB2, PRG2, ENPEP, PRCP, PREP, MEP1A, AGTR2, KNG1, MAS1, EWSR1, CMA1, CTSG, AGTR1, AGT, DNPEP,
    Protein Size: 485
    Poids moléculaire
    53 kDa
    ID gène
    183
    NCBI Accession
    NM_000029, NP_000020
    UniProt
    P01019
    Pathways
    Signalistation JAK/STAT, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity
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