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HGF anticorps (N-Term)

HGF Reactivité: Humain, Rat, Souris, Chien, Mouton, Lapin, Boeuf (Vache), Cheval, Cobaye, Porc, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2781816
  • Antigène Voir toutes HGF Anticorps
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Épitope
    • 16
    • 15
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 81
    • 32
    • 31
    • 15
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien, Mouton, Lapin, Boeuf (Vache), Cheval, Cobaye, Porc, Poisson zèbre (Danio rerio)
    Hôte
    • 70
    • 22
    • 4
    • 1
    Lapin
    Clonalité
    • 76
    • 21
    Polyclonal
    Conjugué
    • 47
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HGF est non-conjugé
    Application
    • 88
    • 37
    • 30
    • 14
    • 13
    • 13
    • 12
    • 12
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    VKKEFGHEFD LYENKDYIRN CIIGKGRSYK GTVSITKSGI KCQPWSSMIP
    Specificité
    100 % homologous to all 6 isoforms, 1 (83 kDa), 2 (34 kDa), 3 (83 kDa), 4 (35 kDa), 5 (33 kDa), 6 (24 kDa)
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 80%
    Attributs du produit
    This is a rabbit polyclonal antibody against HGF. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human HGF
    Top Product
    Discover our top product HGF Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 728 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Nejak-Bowen, Orr, Bowen, Michalopoulos: "Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy." dans: PLoS ONE, Vol. 8, Issue 3, pp. e59836, (2013) (PubMed).

    Ji, Zhang, You, Li, Liu, Jiang, Liu, Zhang, Wang, Tao, Dou: "The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice." dans: Biomaterials, Vol. 33, Issue 35, pp. 8995-9008, (2012) (PubMed).

    Zampell, Avraham, Yoder, Fort, Yan, Weitman, Mehrara: "Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines." dans: American journal of physiology. Cell physiology, Vol. 302, Issue 2, pp. C392-404, (2012) (PubMed).

    Sen, Peng, Saigal, Williams, Johnson: "Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 3, pp. 514-24, (2011) (PubMed).

    Williams, Mehta, Peyton, Zeiger, Van Vliet, Griffith: "Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays." dans: Tissue engineering. Part A, Vol. 17, Issue 7-8, pp. 1055-68, (2011) (PubMed).

  • Antigène
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Autre désignation
    HGF (HGF Produits)
    Synonymes
    anticorps DFNB39, anticorps F-TCF, anticorps HGFB, anticorps HPTA, anticorps SF, anticorps HGF, anticorps C230052L06Rik, anticorps HGF/SF, anticorps NK1, anticorps NK2, anticorps SF/HGF, anticorps hepatocyte growth factor, anticorps HGF, anticorps Hgf
    Sujet
    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
    Alias Symbols: F-TCF, HGFB, HPTA, SF, DFNB39
    Protein Interaction Partner: ADAMTSL4, MEOX2, MET, F11, ST14, HGFAC, LCN2, KLKB1, VTN, PLAU, CLEC3B, SDC1, SDC2, HPN, HGF, FN1, NRP1,
    Protein Size: 728
    Poids moléculaire
    83 kDa
    ID gène
    3082
    NCBI Accession
    NM_001010932, NP_001010932
    UniProt
    P14210
    Pathways
    Signalisation RTK, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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